...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Extinction is not a sufficient condition to prevent fear memories from undergoing reconsolidation in the basolateral amygdala.
【24h】

Extinction is not a sufficient condition to prevent fear memories from undergoing reconsolidation in the basolateral amygdala.

机译：灭绝不是防止恐惧记忆在基底外侧杏仁核中重新整合的充分条件。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Consolidated memories when reactivated may return to a state that requires protein synthesis in order to be restabilized (reconsolidation). It has been shown in a variety of systems that if reactivation induces significant extinction then extinction is the protein synthesis dependent memory state, rather than reconsolidation. Thus, extinction consolidation may prevent the memory from undergoing reconsolidation. We investigated whether such an interaction also exists between extinction and reconsolidation of fear memories within the amygdala, by using a within subjects experimental design. We found that inhibition of protein synthesis in the basolateral amygdala (BLA) impaired reconsolidation for both the briefly reactivated and extinguished fear memories suggesting that extinction is not a sufficient condition to prevent induction of reconsolidation in the amygdala. These findings demonstrate that extinction consolidation does not always interact with reconsolidation. Therefore, under these conditions,extinction is not a boundary condition on reconsolidation of fear memories in the basolateral amygdala.
机译：合并的记忆在重新激活后可能会返回到需要蛋白质合成才能稳定的状态（重新整合）。在多种系统中已经表明，如果再活化引起明显的灭绝，则灭绝是蛋白质合成依赖性的记忆状态，而不是巩固。因此，灭绝合并可能会阻止内存进行重新合并。通过研究对象内的实验设计，我们研究了杏仁核内恐惧记忆的消退与巩固之间是否还存在这种相互作用。我们发现抑制在基底外侧杏仁核（BLA）中的蛋白质合成削弱了短暂激活和消失的恐惧记忆的再巩固，提示灭绝不是防止在杏仁核中诱导再巩固的充分条件。这些发现表明，灭绝巩固并不总是与再巩固相互作用。因此，在这些条件下，灭绝不是重新建立基底外侧杏仁核恐惧记忆的边界条件。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号