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首页> 外文期刊>The European Journal of Neuroscience >The vomeronasal organ is required for the expression of lordosis behaviour, but not sex discrimination in female mice.
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The vomeronasal organ is required for the expression of lordosis behaviour, but not sex discrimination in female mice.

机译：在雌性小鼠中表达脊柱前凸行为需要犁鼻鼻器官，而性别则不需要。

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摘要

The role of the vomeronasal organ (VNO) in mediating neuroendocrine responses in female mice is well known; however, whether the VNO is equally important for sex discrimination is more controversial as evidence exists for a role of the main olfactory system in mate recognition. Therefore, we studied the effect of VNO removal (VNOx) on the ability of female mice to discriminate between volatile and non-volatile odours of conspecifics of the two sexes and in different endocrine states using Y-maze tests. VNOx female mice were able to reliably distinguish between male and female or male and gonadectomized (gdx) male volatile odours. However, when subjects had to discriminate between male and female or gdx male non-volatile odours, VNOx females were no longer able to discriminate between sex or different endocrine status. These results thus show that the VNO is primarily involved in the detection and processing of non-volatile odours, and that female mice can use volatile odours detected and processed by the main olfactory system for mate recognition. However, VNO inputs are needed to promote contact with the male, including facilitation of lordosis responses to his mounts. A single subcutaneous injection with gonadotropin-releasing hormone (GnRH) partially reversed the deficit in lordosis behaviour observed in VNOx females suggesting that VNO inputs may reach hypothalamic GnRH neurons to influence the display of sexual behaviour.
机译：在雌性小鼠中，犁鼻鼻器官（VNO）在介导神经内分泌反应中的作用是众所周知的。然而，由于存在主要嗅觉系统在伴侣识别中的作用的证据，因此VNO是否对性别歧视同样重要还存在争议。因此，我们使用Y-迷宫测试研究了VNO去除（VNOx）对雌性小鼠区分两性同种异型和不同内分泌状态的挥发性和非挥发性气味的能力的影响。 VNOx雌性小鼠能够可靠地区分雄性和雌性，以及雄性和去角质化（gdx）雄性挥发性气味。但是，当受试者必须区分男性和女性或gdx男性非挥发性气味时，VNOx女性不再能够区分性别或不同的内分泌状态。因此，这些结果表明，VNO主要参与非挥发性气味的检测和处理，雌性小鼠可以使用主要嗅觉系统检测和处理的挥发性气味来进行配偶识别。但是，需要VNO输入来促进与男性的接触，包括促进脊柱前凸对其坐骑的反应。单次皮下注射促性腺激素释放激素（GnRH）可以部分逆转VNOx雌性中观察到的脊柱前凸行为的缺陷，这表明VNO输入可能到达下丘脑GnRH神经元，从而影响性行为的表现。

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