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首页> 外文期刊>The European Journal of Neuroscience >A novel type of cold-sensitive neuron in rat dorsal root ganglia with rapid adaptation to cooling stimuli.
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A novel type of cold-sensitive neuron in rat dorsal root ganglia with rapid adaptation to cooling stimuli.

机译：大鼠背根神经节中的一种新型的冷敏感神经元，具有快速适应冷却刺激的能力。

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摘要

Cold sensing in mammals is heterogeneous and more than one type of receptor molecule is likely to be involved in the transduction process. Most features of innocuous cold receptors have been explained by TRPM8, the cold and menthol receptor, but their fast adaptation to cooling has not yet been reproduced in cellular systems. In this study we have used a newly developed system for applying fast thermal stimuli to dissociated dorsal root ganglia (DRG) neurons from young rats (150-200 g) in primary culture. We describe a novel type of cold-sensitive rat DRG neuron with rapid adaptation to cooling. These cells (4.3% of the total DRG population) do not express either TRPM8 or the other cold-activated TRP channel, TRPA1, and the epithelial sodium channel (ENaC) is not involved in their transduction. Increases in intracellular calcium induced by cooling in rapidly adapting neurons are caused by calcium entry. These neurons express a large and rapidly adapting cold-induced inward current with a time constant of adaptation in the seconds range, and may correspond to the rapidly adapting cold receptors described in vivo.
机译：哺乳动物的冷感是异质的，并且转导过程可能涉及一种以上的受体分子。无害的冷受体的大多数特征已经通过TRPM8（冷和薄荷醇受体）进行了解释，但是在细胞系统中尚未再现出它们对冷却的快速适应性。在这项研究中，我们使用了一种新开发的系统，该系统将快速热刺激应用于原代培养中年轻大鼠（150-200 g）的离体背根神经节（DRG）神经元。我们描述了一种新型的冷敏感大鼠DRG神经元，具有快速适应冷却的能力。这些细胞（占总DRG群体的4.3％）既不表达TRPM8也不表达其他冷激活的TRP通道TRPA1，上皮钠通道（ENaC）不参与其转导。快速适应性神经元的冷却诱导的细胞内钙增加是由钙进入引起的。这些神经元表达大的且快速适应的冷诱导的内向电流，其适应时间常数在数秒范围内，并且可以对应于体内描述的快速适应的冷受体。

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