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首页> 外文期刊>The European Journal of Neuroscience >Extracellular matrix molecules and synaptic plasticity: immunomapping of intracellular and secreted Reelin in the adult rat brain.
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Extracellular matrix molecules and synaptic plasticity: immunomapping of intracellular and secreted Reelin in the adult rat brain.

机译：细胞外基质分子和突触可塑性：成年大鼠大脑中细胞内和分泌的Reelin的免疫作图。

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摘要

Reelin, a large extracellular matrix glycoprotein, is secreted by several neuron populations in the developing and adult rodent brain. Secreted Reelin triggers a complex signaling pathway by binding lipoprotein and integrin membrane receptors in target cells. Reelin signaling regulates migration and dendritic growth in developing neurons, while it can modulate synaptic plasticity in adult neurons. To identify which adult neural circuits can be modulated by Reelin-mediated signaling, we systematically mapped the distribution of Reelin in adult rat brain using sensitive immunolabeling techniques. Results show that the distribution of intracellular and secreted Reelin is both very widespread and specific. Some interneuron and projection neuron populations in the cerebral cortex contain Reelin. Numerous striatal neurons are weakly immunoreactive for Reelin and these cells are preferentially located in striosomes. Some thalamic nuclei contain Reelin-immunoreactive cells. Double-immunolabeling for GABA and Reelin reveals that the Reelin-immunoreactive cells in the visual thalamus are the intrinsic thalamic interneurons. High local concentrations of extracellular Reelin selectively outline several dendrite spine-rich neuropils. Together with previous mRNA data, our observations suggest abundant axoplasmic transport and secretion in pathways such as the retino-collicular tract, the entorhino-hippocampal ('perforant') path, the lateral olfactory tract or the parallel fiber system of the cerebellum. A preferential secretion of Reelin in these neuropils is consistent with reports of rapid, activity-induced structural changes in adult brain circuits.
机译：Reelin是一种大型的细胞外基质糖蛋白，由发育中和成年啮齿动物大脑中的几个神经元群体分泌。分泌的Reelin通过结合靶细胞中的脂蛋白和整联蛋白膜受体来触发复杂的信号通路。 Reelin信号传导调节发育中神经元的迁移和树突状生长，同时它可以调节成年神经元中的突触可塑性。为了确定哪些Reelin介导的信号可以调节成年神经回路，我们使用敏感的免疫标记技术系统地绘制了Reelin在成年大鼠脑中的分布。结果表明，细胞内和分泌的Reelin的分布非常广泛且特定。大脑皮层中的一些中间神经元和投射神经元种群含有Reelin。许多纹状体神经元对Reelin的免疫反应较弱，并且这些细胞优先位于粒状体中。某些丘脑核含有Reelin免疫反应性细胞。 GABA和Reelin的双重免疫标记显示，视觉丘脑中Reelin免疫反应性细胞是固有的丘脑中神经元。高局部浓度的细胞外Reelin选择性地勾勒出几个富含树突棘的神经柱。连同以前的mRNA数据，我们的观察结果表明，在诸如视网膜-胶束束，内嗅-海马（“穿孔”）通道，外侧嗅觉通道或小脑平行纤维系统等途径中，大量的质体转运和分泌。这些神经纤维中Reelin的优先分泌与成人大脑回路中快速，活动性诱导的结构变化的报道一致。

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