...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Uncoupling protein-2 promotes nigrostriatal dopamine neuronal function.
【24h】

Uncoupling protein-2 promotes nigrostriatal dopamine neuronal function.

机译：解偶联蛋白2促进黑质纹状体多巴胺神经元功能。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Uncoupling protein 2 (UCP2) is known to promote neuroprotection in many forms of neurological pathologies including Parkinson's disease. Here, we examined the hypothesis that UCP2 also mediates aspects of normal nigrostriatal dopamine (DA) function. Mice lacking UCP2 exhibited reduced dopamine turnover in the striatum as measured by the 3,4-dihydoxyphenylacetic acid/dopamine (DOPAC/DA) ratio, reduced tyrosine hydroxylase immunoreactivity (TH IR) in the substantia nigra pars compacta (SNc) and reticulata, striatum and nucleus accumbens. UCP2-knockout (KO) mice also had reduced dopamine transporter immunoreactivity (DAT IR) in the SNc but not other brain regions examined. In order to determine if these biochemical deficits are transcribed into behavioural deficits, we examined locomotor function in UCP2-KO mice compared to wild-type (WT) controls. UCP2-KO mice exhibited significantly reduced total movement distance, movement velocity and increased rest time compared to wild-type controls. These results suggest that UCP2 is an important mitochondrial protein that helps to maintain normal nigrostriatal dopamine neuronal function and a reduction in UCP2 levels may predispose individuals to environmental causes of Parkinson's disease.
机译：已知解偶联蛋白2（UCP2）可以在包括帕金森氏病在内的许多神经病理学形式中促进神经保护作用。在这里，我们检查了UCP2还介导正常的黑纹状体多巴胺（DA）功能方面的假设。缺乏UCP2的小鼠在纹状体中表现出降低的多巴胺转化率，这是通过3,4-二羟基苯乙酸/多巴胺（DOPAC / DA）比率测得的，黑质致密部（SNc）和网状纹状体中的酪氨酸羟化酶免疫反应性（TH IR）降低了和伏隔核UCP2-基因敲除（KO）小鼠的SNc中多巴胺转运蛋白的免疫反应性（DAT IR）也降低了，但其他大脑区域却没有。为了确定这些生化缺陷是否被转录为行为缺陷，我们检查了UCP2-KO小鼠与野生型（WT）对照相比的运动功能。与野生型对照相比，UCP2-KO小鼠表现出明显减少的总运动距离，运动速度和增加的休息时间。这些结果表明，UCP2是一种重要的线粒体蛋白，有助于维持正常的黑纹状体多巴胺神经元功能，UCP2含量的降低可能使人容易患上帕金森氏病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号