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首页> 外文期刊>The European Journal of Neuroscience >Restorative respiratory pathways after partial cervical spinal cord injury: role of ipsilateral phrenic afferents.
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Restorative respiratory pathways after partial cervical spinal cord injury: role of ipsilateral phrenic afferents.

机译：颈部分脊髓损伤后的恢复性呼吸途径：同侧传入的作用。

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摘要

After disruption of the descending respiratory pathways induced by unilateral cervical spinal cord injury (SCI) in rats, the inactivated ipsilateral (ipsi) phrenic nerve (PN) discharge may partially recover following some specific experimental procedures [such as contralateral (contra) phrenicotomy (Phx)]. This phrenic reactivation involves normally silent contra pathways decussating at the level of the phrenic nucleus, but the mechanisms of this crossed phrenic activation are still poorly understood. The present study investigates the contribution of sensory phrenic afferents to this process by comparing the acute effects of ipsi and contra Phx. We show that the phrenic discharge (recorded on intact PNs) was almost completely suppressed 0 h and 3 h after a lateral cervical SCI, but was already spontaneously reactivated after 1 week. This ipsi phrenic activity was enhanced immediately after contra Phx and was completely suppressed by an acute contra cervical section, indicating that it is triggered by crossed phrenic pathways located laterally in the contra spinal cord. Ipsi phrenic activity was also abolished immediately after ipsi Phx that interrupts phrenic sensory afferents, an effect prevented by prior acute ablation of the cervical dorsal root ganglia, indicating that crossed phrenic activation depends on excitatory phrenic sensory afferents but also putatively on inhibitory non-phrenic afferents. On the basis of these data, we propose a new model for crossed phrenic activation after partial cervical injury, with an essential role played by ipsi-activating phrenic sensory afferents.
机译：在大鼠单侧颈脊髓损伤（SCI）引起的下行呼吸路径中断后，灭活的同侧（ipsi）nerve神经（PN）放电可能会通过一些特定的实验程序[例如对侧（对侧）开颅手术（Phx ）]。这种激活通常涉及在contra核水平上沉默的反向路径，但是这种crossed激活的机制仍然知之甚少。本研究通过比较ipsi和contra Phx的急性作用来研究感觉传入对这一过程的贡献。我们显示a气放电（记录在完整的PNs上）在侧颈SCI后0 h和3 h几乎被完全抑制，但在1周后已经自发激活。对位Phx后，这种ipsi活动被立即增强，并被急性对位颈段完全抑制，表明它是由位于对侧脊髓的横向crossed通路触发的。在ipsi Phx中断感觉传入后，ipsi activity活动也立即被取消，这种作用被先前的子宫颈背根神经节的急性消融所阻止，表明交叉crossed激活取决于兴奋性感觉传入，但也取决于抑制性非non传入。 。根据这些数据，我们提出了部分宫颈损伤后交叉crossed激活的新模型，该模型具有激活ipsi激活sensor感觉传入的重要作用。

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