Translin-associated factor-X (Trax) is a molecular switch of growth-associated protein (GAP)-43 that controls axonal regeneration.

Schroer U; Volk GF; Liedtke T; Thanos S

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Translin-associated factor-X (Trax) is a molecular switch of growth-associated protein (GAP)-43 that controls axonal regeneration.

机译：Translin相关因子X（Trax）是控制轴突再生的生长相关蛋白（GAP）-43的分子开关。

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The ability of neurons to form axons requires the choreographed assembly of growth cones. We show that there is a time window from postnatal day 14 (P14) until P21/22 when axons of rat retinal ganglion cells will regenerate under serum-free culture conditions. In contrast, no outgrowth occurred before P13, and growth declined from P22 and ceased after P30. Using proteomics, we have identified translin-associated factor X (Trax), a DNA-binding factor that is expressed during this period of postnatal development. Trax is shown to coexpress with growth-associated protein GAP-43. Small interfering RNA-mediated inhibition of Trax expression resulted in downregulation of both Trax and GAP-43 transcripts and protein both before and during the period of regeneration (P8) and (P16). In contrast, silencing of Trax at P30 resulted in significant upregulation of the GAP-43 transcript and protein and induced outgrowth of axons. These data suggest that Trax regulates GAP-43 transcription and regeneration-promoting effects during the postnatal maturation period. Trax may represent a new potent therapeutic target gene for optic nerve and spinal cord injuries.

机译：神经元形成轴突的能力需要编排生长锥。我们显示，从出生后第14天（P14）到P21 / 22，当大鼠视网膜神经节细胞轴突在无血清培养条件下再生时，会有一个时间窗口。相反，在P13之前没有发生生长，并且从P22下降并在P30之后停止增长。使用蛋白质组学，我们已经确定了转蛋白相关因子X（Trax），这是一种在出生后发育阶段表达的DNA结合因子。 Trax与生长相关蛋白GAP-43共表达。 RNA介导的Trax表达抑制作用较小，导致再生之前（P8）和（P16）期间和期间Trax和GAP-43转录本和蛋白质均下调。相比之下，P30时Trax的沉默导致GAP-43转录本和蛋白质的显着上调，并导致轴突生长。这些数据表明，Trax在产后成熟期间调节GAP-43转录和促进再生的作用。 Trax可能代表视神经和脊髓损伤的新的有效治疗靶基因。

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《The European Journal of Neuroscience》 |2007年第8期|共10页
作者
Schroer U; Volk GF; Liedtke T; Thanos S;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
growth aspects; Natural regeneration; Proteins; GAP-43 Protein; 蛋白质类; GAP-43蛋白;

机译：growth aspects;Natural regeneration;Proteins;GAP-43 Protein;蛋白质类;GAP-43蛋白;

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1. Translin-associated factor-X (Trax) is a molecular switch of growth-associated protein (GAP)-43 that controls axonal regeneration. [J] . Schroer U, Volk GF, Liedtke T, The European Journal of Neuroscience . 2007,第8期

机译：Translin相关因子X（Trax）是控制轴突再生的生长相关蛋白（GAP）-43的分子开关。
2. Contact with astroglial membranes induces axonal and dendritic growth of human CNS model neurons and affects the distribution of the growth-associated proteins MAP1B and GAP43. [J] . Piontek Jorg, Regnier-Vigouroux Anne, Brandt Roland Journal of Neuroscience Research . 2002,第4期

机译：与星形胶质细胞膜的接触可诱导人CNS模型神经元的轴突和树突状生长，并影响与生长相关的蛋白质MAP1B和GAP43的分布。
3. A Shift from a Pivotal to Supporting Role for the Growth-Associated Protein (GAP-43) in the Coordination of Axonal Structural and Functional Plasticity [J] . Matthew R. Holahan Frontiers in Cellular Neuroscience . 2017,第2004期

机译：生长相关蛋白（GAP-43）在轴突结构和功能可塑性的协调中从关键角色转变为支持角色。
4. Spatio-Temporal Dissection of Protein Kinase C-Mediated Phosphorylation of the Gap Junction Protein Connexin43 [C] . A.C. Cone, A.X. Wu-Zhang, A.C. Newton, Microscopy Society of America Annual Meeting;Microanalysis Society Annual meeting;International Metallographic Society Annual meeting . 2012

机译：时空解剖的蛋白激酶C介导的间隙连接蛋白Connexin43的磷酸化。
5. Growth-associated protein-43 (GAP-43) and heat shock cognate 70 (HSC70)mRNA and protein expression during the acquisition of a spatial memory task. [D] . Pizarro-Matos, Jose Manuel. 2002

机译：在获得空间记忆任务期间，与生长相关的蛋白43（GAP-43）和热休克同源70（HSC70）mRNA和蛋白表达。
6. A Shift from a Pivotal to Supporting Role for the Growth-Associated Protein (GAP-43) in the Coordination of Axonal Structural and Functional Plasticity [O] . Matthew R. Holahan 2017

机译：生长相关蛋白（GAP-43）在轴突结构和功能可塑性的协调中从关键角色转变为支持角色。
7. A Shift from a Pivotal to Supporting Role for the Growth-Associated Protein (GAP-43) in the Coordination of Axonal Structural and Functional Plasticity [O] . Matthew R. Holahan 2017

机译：轴突结构和功能可塑性协调中从生长相关蛋白（Gap-43）的关键转变为支持作用
8. Neuron-Specific Protein F1/GAP-43 Shows Substrate Specificity for the BetaSubtype of Protein Kinase C [R] . Sheu, F. S., Marais, R. M., Parker, P. J., 1990

机译：神经元特异性蛋白F1 / Gap-43显示蛋白激酶C的β亚型的底物特异性

Translin-associated factor-X (Trax) is a molecular switch of growth-associated protein (GAP)-43 that controls axonal regeneration.

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