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首页> 外文期刊>The European Journal of Neuroscience >The effect of CB(1) receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats.
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The effect of CB(1) receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats.

机译：右基底外侧杏仁核中CB（1）受体拮抗作用对大鼠条件性恐惧和相关镇痛的作用。

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The endocannabinoid system mediates analgesia expressed following exposure to conditioned or unconditioned aversive stimuli, and controls the extinction of conditioned aversive behaviour. The present study investigated the effects of administration of the cannabinoid(1) (CB(1)) receptor antagonist SR141716A into the right basolateral amygdala (BLA) on expression of conditioned fear, formalin-evoked nociceptive behaviour, fear-conditioned analgesia and associated alterations in monoamine levels in discrete rat brain areas. Re-exposure to a context previously paired with footshock significantly reduced formalin-evoked nociceptive behaviour. Intra-BLA administration of SR141716A did not attenuate fear-conditioned analgesia, but reduced formalin-evoked nociceptive behaviour and attenuated the formalin-induced decrease in freezing and 22-kHz ultrasonic vocalizations in the early part of the trial. Furthermore, intra-BLA SR141716A significantly prolonged the duration of these fear-related behaviours in fear-conditioned rats not receiving formalin. Fear-conditioned analgesia was accompanied by increased homovanillic acid (HVA) : dopamine (DA) ratio and reduced serotonin (5-HT) in the cerebellum, an effect not altered by SR141716A. SR141716A-induced analgesia was accompanied by reduced DA, increased HVA : DA ratio and reduced 5-HT levels in the cerebellum, increased hippocampal HVA levels and increased 5-hydroxyindole-3-acetic acid (5-HIAA) in the amygdaloid cortex. The SR141716A-induced prolongation of contextually induced aversive behaviour was accompanied by reduced DA and 3,4-dihyroxyphenylacetic acid (DOPAC), levels in the hippocampus, and increased DA and 5-HIAA in the periaqueductal grey. These data suggest an important role for CB(1) receptors in the right BLA in mediating short-term extinction of conditioned aversive behaviour but not fear-conditioned analgesia. The results also enhance our understanding of endocannabinoid-monoamine interactions of relevance to conditioned fear and associated analgesia.
机译：内源性大麻素系统介导暴露于条件性或非条件性厌恶刺激后表达的镇痛作用，并控制条件性厌恶行为的消亡。本研究调查了向右基底外侧杏仁核（BLA）施用大麻素（1）（CB（1））受体拮抗剂SR141716A对条件性恐惧，福尔马林诱发的伤害性行为，恐惧性镇痛和相关改变的表达的影响在离散大鼠大脑区域的单胺水平。再次暴露于先前与足部震颤相伴的环境下，福尔马林诱发的伤害性行为明显减少。在试验的早期阶段，SR141716A的BLA内给药并未减轻恐惧条件镇痛作用，但减少了福尔马林引起的伤害感受行为，并减轻了福尔马林引起的冰冻和22 kHz超声发声的降低。此外，在未接受福尔马林的恐惧条件大鼠中，BLA内SR141716A显着延长了这些恐惧相关行为的持续时间。恐惧条件下的镇痛伴随着高香草酸（HVA）：多巴胺（DA）比例的增加和小脑中5-羟色胺（5-HT）的降低，SR141716A并没有改变这种效果。 SR141716A诱导的镇痛伴随着DA减少，HVA：DA比增加和小脑5-HT含量降低，海马HVA含量升高以及杏仁核皮质中5-羟吲哚-3-乙酸（5-HIAA）含量增加。 SR141716A诱导的情境诱导的厌恶行为的延长伴有DA和3,4-二羟氧苯基乙酸（DOPAC）降低，海马中的水平以及导水管周围灰色区DA和5-HIAA的升高。这些数据表明右BLA中的CB（1）受体在介导条件性厌恶行为的短期灭绝而不是恐惧条件性镇痛中的重要作用。结果还增强了我们对与条件性恐惧和相关镇痛有关的内源性大麻素-单胺相互作用的理解。

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