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首页> 外文期刊>The European Journal of Neuroscience >Distinct contributions of frontal areas to emotion and social behaviour in the rat.
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Distinct contributions of frontal areas to emotion and social behaviour in the rat.

机译：额叶对大鼠情绪和社交行为的不同贡献。

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Although the lesions of patients with impaired social behaviour encompass both orbitofrontal and anterior cingulate cortex (OFC and ACC), attempts to model such impairments in animals have focused on the OFC. However, recent neuroimaging attempts to identify the neural correlates of social interaction have emphasized the relative importance of ACC. Here we report the effect of circumscribed excitotoxic lesions of either OFC or ACC on ethological, unconditioned tests of emotion and social behaviour in the Lister hooded rat. OFC lesions altered emotional responsiveness to stimuli in non-social, fear-inducing situations (hyponeophagia test), and produced a small but statistically significant increase in aggression to other rats, but did not compromise other aspects of social interaction and appraisal. ACC lesions did, however, affect the utilization of social information. Specifically, ACC lesions diminished interest in other individuals and caused a relative reduction in memory for social stimuli. Whereas normal animals habituated to repeated presentations of the same individual, the poor performance of ACC animals entailed continued higher levels of responsiveness to repeated presentations of the same individual. The ACC impairment cannot simply be attributed to a general reduction in arousal, or a general impairment in recognition memory. Neither lesion affected anxiety per se (successive alleys test). Further analyses were conducted to investigate whether the changes in aggressive and social behaviour were related to different aspects of decision-making. Although the relationship between changes in social interaction and decision-making after ACC lesions is unclear, OFC impairments in emotionality were correlated with increased impulsive choice.
机译：尽管社交行为受损的患者的病变包括眶额叶和前扣带回皮质（OFC和ACC），但在动物中模拟此类损伤的尝试却集中在OFC上。然而，最近的神经影像学试图识别社交互动的神经相关性，已经强调了ACC的相对重要性。在这里，我们报道了OFC或ACC限制的兴奋性毒性损害对李斯特（Lister）蒙面大鼠的行为学，情绪和社交行为的无条件测试的影响。在非社交，诱发恐惧的情况下，OFC损伤改变了对刺激的情绪反应（吞噬性试验），对其他老鼠的攻击行为增加了很小但有统计学意义的增加，但并未影响社交互动和评估的其他方面。但是，ACC病变确实影响了社会信息的利用。具体而言，ACC病变会减少对其他个体的兴趣，并导致社交刺激记忆的相对减少。正常动物习惯于重复呈现同一个人，而ACC动物的不良表现导致其对同一个人重复呈现的反应性持续较高水平。 ACC损害不能简单地归因于唤醒的普遍减少或识别记忆的普遍损害。两种病变本身都不会影响焦虑（成功的小巷测试）。进行了进一步的分析，以调查侵略性和社会行为的变化是否与决策的不同方面有关。尽管不清楚ACC病变后社交互动的变化与决策之间的关系，但OFC情绪障碍与冲动选择增加有关。

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