...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Physiological effects of auditory nerve myelinopathy in chinchillas.
【24h】

Physiological effects of auditory nerve myelinopathy in chinchillas.

机译：龙猫听神经脊髓病的生理效应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The goals were to study the physiological effects of auditory nerve myelinopathy in chinchillas and to test the hypothesis that myelin abnormalities could account for auditory neuropathy, a hearing disorder characterized by absent auditory brainstem responses (ABRs) with preserved outer hair cell function. Doxorubicin, a cytotoxic drug used as an experimental demyelinating agent, was injected into the auditory nerve bundle of 18 chinchillas; six other chinchillas were injected with vehicle alone. Cochlear microphonics, compound action potentials (CAPs), inferior colliculus evoked potentials (IC-EVPs), cubic distortion product otoacoustic emissions and ABRs were recorded before and up to 2 months after injection. Cochleograms showed no hair cell loss in any of the animals and measures of outer hair cell function were normal (cubic distortion product otoacoustic emissions) or enhanced (cochlear microphonics) after injection. ABR was present in animals with mild myelin damage (n = 10) and absent in animals with severe myelin damage that included the myelin surrounding spiral ganglion cell bodies and fibers in Rosenthal's canal (n = 8). Animals with mild damage had reduced response amplitudes at 1 day, followed by recovery of CAP and enhancement of the IC-EVP. In animals with severe damage, CAP and IC-EVP thresholds were elevated, amplitudes were reduced, and latencies were prolonged at 1 day and thereafter. CAPs deteriorated over time, whereas IC-EVPs partially recovered; latencies remained consistently prolonged despite changes in amplitudes. The results support auditory nerve myelinopathy as a possible pathomechanism of auditory neuropathy but indicate that myelinopathy must be severe before physiological measures are affected.
机译：目的是研究龙猫的听觉神经脊髓病的生理学作用，并检验髓鞘异常可以解释听觉神经病的假说，听觉神经病是一种听觉脑干反应（ABR）缺失且外毛细胞功能得以保留的听力障碍。阿霉素，一种用作实验性脱髓鞘剂的细胞毒性药物，被注入18只龙猫的听神经束中。其他六个龙猫单独注射了媒介物。在注射前和注射后两个月内记录耳蜗的声音，复合动作电位（CAPs），下丘脑诱发电位（IC-EVPs），立方畸变产物耳声发射和ABR。耳蜗图未显示任何动物的毛细胞丢失，注射后外部毛细胞功能的测量值正常（立方变形产物耳声发射）或增强（耳蜗微音）。 ABR存在于轻度髓鞘损害的动物中（n = 10），而在严重髓鞘损害的动物中不存在，其中包括髓鞘周围的螺旋神经节细胞体和卢森塔尔管中的纤维（n = 8）。具有轻度损伤的动物在1天时反应幅度降低，然后恢复CAP和增强IC-EVP。在遭受严重伤害的动物中，CAP和IC-EVP阈值升高，幅度降低，潜伏期在1天及以后延长。 CAP随时间推移而恶化，而IC-EVP则部分恢复;尽管幅度有所变化，但延迟始终保持不变。结果支持听神经脊髓病是听神经病的一种可能的发病机制，但表明在影响生理措施之前，脊髓病必须是严重的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号