...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Phasic and tonic firing properties in rat oculomotor nucleus motoneurons, studied in vitro.
【24h】

Phasic and tonic firing properties in rat oculomotor nucleus motoneurons, studied in vitro.

机译：在体外研究大鼠动眼神经元运动神经元的相和强直放电特性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Alert-chronic studies show that ocular motoneurons (Mns) exhibit a phasic and tonic firing correlated with eye saccade-velocity and position (fixation), respectively. Differences in the phasic and tonic firing among Mns depend on synaptic inputs and/or the intrinsic membrane properties. We have used in vitro slice preparation to investigate the contribution of membrane properties to firing properties of Wistar rat oculomotor nucleus Mns. We recorded different discharge patterns and focused on Mns with sustained discharge (type I) because they were the most abundant, and their firing pattern resembles that reported in alert preparations. Various differences divided these Mns into types I(A) and I(B); the afterhyperpolarization (AHP) phase of the spike was monophasic in I(A) and biphasic in I(B); I(A) Mns showed tonic or phasic-tonic firing depending on the current intensity, while I(B) Mns showed phasic-tonic discharge; the phasic firing was higher in I(B) than in I(A) Mns; I(A) Mns fired in a narrower range than did I(B) Mns; and I(A) Mns showed lower maximum frequency than did I(B) Mns. In conclusion, I(A) and I(B) Mns show different phasic firing properties and dynamic range, supported by intrinsic membrane properties. We suggest that I(A) and I(B) Mns innervate fast-twitch muscle fibres with different contraction speeds, and could contribute to generating a fine phasic signal for a graded muscle contraction. Finally, we have demonstrated an inverse relationship between Mn thresholds and tonic firing gain, concluding that intrinsic membrane properties could not support the covariation between tonic firing gain and recruitment thresholds reported in alert studies.
机译：长期警报研究表明，眼运动神经元（Mns）表现出相变和强直性放电，分别与眼扫视速度和位置（固定）相关。 Mns之间的相位和张力射击的差异取决于突触输入和/或固有的膜特性。我们已使用体外切片制备来研究膜特性对Wistar大鼠动眼神经核Mns放电特性的贡献。我们记录了不同的放电模式，并着眼于持续放电的Mns（I型），因为它们含量最高，并且其放电模式类似于警报准备中报告的那样。各种差异将这些Mns分为I（A）和I（B）类型。峰值的超极化后（AHP）相在I（A）中为单相，在I（B）中为双相。根据电流强度，I（A）Mns会显示出强音或相声放电，而I（B）Mns则显示出相声放电。 I（B）的相位发射高于I（A）的Mns; I（A）Mns的发射范围比I（B）Mns的发射范围窄; I（A）Mns的最大频率低于I（B）Mns。总之，I（A）和I（B）Mns表现出不同的相位触发特性和动态范围，并受到固有膜特性的支持。我们建议I（A）和I（B）Mns以不同的收缩速度神经支配快速抽搐的肌纤维，并可能有助于产生精细的阶段性信号，以进行分级的肌肉收缩。最后，我们证明了Mn阈值与滋补素释放量之间存在反比关系，认为固有的膜特性不能支持警戒研究中报道的滋补素释放量与补充阈值之间的协方差。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号