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首页> 外文期刊>The European Journal of Neuroscience >Repetitive transcranial magnetic stimulation over the primary motor cortex disrupts early boost but not delayed gains in performance in motor sequence learning.
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Repetitive transcranial magnetic stimulation over the primary motor cortex disrupts early boost but not delayed gains in performance in motor sequence learning.

机译：在原发性运动皮层上重复经颅磁刺激可破坏早期增强，但不会延迟运动序列学习中的表现。

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摘要

In humans the consolidation of recently learned motor skills is a multi-step process. We previously showed that performance on the finger-tapping task (FTT; i.e. a sequential motor skill) temporarily improves early on, 5-30 min after practice has ended, but not 4 h later. In the absence of any further practice to the task, this early boost in performance was predictive of the performance levels eventually achieved 48 h later, suggesting its functional relevance for long-term memory consolidation [Hotermans, Peigneux, Maertens de Noordhout, Moonen, and Maquet (2006) Early boost and slow consolidation in motor skill learning. Learn. Mem., 13, 580-583]. Here, we focused on the role of the primary motor cortex (M1) in consolidation using repetitive transcranial magnetic stimulation (rTMS) applied immediately before testing at 30 min, 4 or 24 h after practice of the FTT. Immediately after learning, rTMS over M1 depressed the early boost in performance, but did not affect the delayed improvement observed 48 h later. Four and 24 h after practice, rTMS did not disrupt performance anymore. These results suggest that M1 supports performance during the early post-training phase of motor skill consolidation, but is no longer mandatory in the subsequent, delayed stages of consolidation.
机译：在人类中，巩固最近学到的运动技能是一个多步骤的过程。我们之前的研究表明，手指敲击任务（FTT;即一种连续的运动技能）的表现会在练习结束后的5-30分钟之初暂时改善，但4小时后才有所改善。在没有任何进一步练习的情况下，这种性能的早期提高预示了48小时后最终将达到的性能水平，表明其与长期记忆整合的功能相关性[Hotermans，Peigneux，Maertens de Noordhout，Mounen和Maquet（2006）在运动技能学习中的早期提倡和缓慢巩固。学习。 Mem。，13，580-583]。在这里，我们重点研究了在练习FTT后30分钟，4或24小时之前使用重复经颅磁刺激（rTMS）施加的主要运动皮层（M1）在巩固中的作用。学习后立即，rTMS超过M1抑制了性能的早期提升，但不影响48小时后观察到的延迟改善。练习后的第4和24小时，rTMS不再影响性能。这些结果表明，M1可在运动技能巩固的训练后早期阶段支持表现，但在随后的巩固阶段则不再是必需的。

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