...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >The effects of running and of inhibiting adult neurogenesis on learning and memory in rats.
【24h】

The effects of running and of inhibiting adult neurogenesis on learning and memory in rats.

机译：跑步和抑制成年神经发生对大鼠学习和记忆的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The presence of ongoing adult neurogenesis within the highly plastic hippocampal circuitry poses questions as to the relevance of new neurons to learning and memory. Correlational and causal evidence suggests that some, but not all, hippocampal tasks involve the new neurons. The evidence with regard to spatial learning in the water maze, one of the most commonly used hippocampal tasks, is contradictory. In this study we examined the effects of irradiation-induced reduction in neurogenesis on spatial learning and another standard hippocampal task, contextual fear conditioning, in rats that experienced normal cage conditions or voluntary running. The results indicate that reduced neurogenesis had little effect on spatial learning but severely impaired contextual fear conditioning. It was suggested that compensatory mechanisms within the hippocampus may have contributed selectively to sparing of spatial function. Performance on the fear conditioning task was weakly related to enhanced neurogenesis or running. The results improve our understanding of the functional role of adult neurogenesis in behaving animals.
机译：在高度可塑性的海马回路中正在进行的成年神经发生的存在提出了关于新神经元与学习和记忆的相关性的问题。相关和因果关系的证据表明，一些而非全部海马任务涉及新的神经元。关于水迷宫中的空间学习（最常用的海马任务之一）的证据是相互矛盾的。在这项研究中，我们研究了正常笼养条件或自愿奔跑的大鼠中，辐射诱导的神经发生减少对空间学习和另一种标准海马任务（情境恐惧调节）的影响。结果表明，减少的神经发生对空间学习几乎没有影响，但严重削弱了情境恐惧条件。有人提出海马内的补偿机制可能有选择地有助于节省空间功能。在恐惧调节任务上的表现与增强的神经发生或奔跑弱相关。结果提高了我们对成年神经发生在行为动物中的功能作用的理解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号