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首页> 外文期刊>The European Journal of Neuroscience >Developmental emergence of transient and persistent hippocampal events and oscillations and their association with infant seizure susceptibility.
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Developmental emergence of transient and persistent hippocampal events and oscillations and their association with infant seizure susceptibility.

机译：暂时性和持续性海马事件和振荡的发育出现及其与婴儿癫痫发作易感性的关系。

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During the second postnatal week in rats, the hippocampus exhibits a transient period of hyperexcitability. To systematically assess the relationship between the onset and end of this period and spontaneous hippocampal activity, we used silicon depth electrodes in unanaesthetized head-fixed rats from postnatal day (P)2 to P18. At all ages, hippocampal sharp waves (SPWs) were prominent in the EEG. Beginning at P6, however, marked changes in SPWs and associated oscillations were detected. SPW-related 'gamma tails' (60-100 Hz) and 'ripples' (140-200 Hz) were first observed at P6 and P7, respectively, and both oscillations persisted up to P18. Transiently, between P6 and P11, SPW duration decreased and the occurrence of SPW doublets increased. In addition, between P8 and P11, a subset of rats exhibited 'spontaneous potentiated SPWs' characterized by double polarity reversals, enhanced likelihood of gamma tails, and population spikes. Having identified a suite of transient hippocampal features consistent with a window of increased excitability, we next assessed whether electrographic seizure activity would be most easily induced during this period. To do this, kainic acid (KA; 200 ng/infusion) was infused into the hippocampus contralateral to the recording probe. KA did not induce seizure activity until P7 and reached peak effectiveness at P9. Thereafter, sensitivity to KA declined. All together, these findings provide in vivo neurophysiological support for the notion of a developmental window of heightened seizure susceptibility during the second postnatal week, and also suggest that spontaneous nonpathological hippocampal activity can be used to mark the onset and end of this period.
机译：在大鼠产后第二周，海马表现出短暂的过度兴奋状态。为了系统地评估此期间的开始和结束与自发海马活动之间的关系，我们在出生后（P）2至P18的未麻醉的头戴固定大鼠中使用了硅深度电极。在所有年龄段，脑电图均显示海马尖波（SPW）。但是，从P6开始，检测到SPW的明显变化以及相关的振荡。与SPW相关的“伽马尾巴”（60-100 Hz）和“波纹”（140-200 Hz）首先分别在P6和P7处观察到，并且两个振荡一直持续到P18。暂时地，在P6和P11之间，SPW持续时间减少，SPW双重峰的出现增加。此外，在P8和P11之间，一部分大鼠表现出“自发增强的SPW”，其特征是双极性反转，伽马尾巴的可能性增加以及种群高峰。确定了一系列与增加兴奋性窗口一致的短暂海马特征后，我们接下来评估了在此期间是否最容易诱发电子照相癫痫发作活动。为此，将海藻酸（KA; 200 ng /输液）注​​入到与记录探针对侧的海马中。直到P7，KA才诱发癫痫发作活动，并在P9达到峰值疗效。此后，对KA的敏感性下降。总之，这些发现为出生后第二周癫痫易感性增高的发育期窗口提供了体内神经生理学支持，也表明自发的非病理性海马活动可用于标记这一时期的开始和结束。

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