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首页> 外文期刊>The European Journal of Neuroscience >Neurotoxic lesions of ventrolateral prefrontal cortex impair object-in-place scene memory.
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Neurotoxic lesions of ventrolateral prefrontal cortex impair object-in-place scene memory.

机译：腹外侧前额叶皮层的神经毒性损害损害了原位物体的场景记忆。

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Disconnection of the frontal lobe from the inferotemporal cortex produces deficits in a number of cognitive tasks that require the application of memory-dependent rules to visual stimuli. The specific regions of frontal cortex that interact with the temporal lobe in performance of these tasks remain undefined. One capacity that is impaired by frontal-temporal disconnection is rapid learning of new object-in-place scene problems, in which visual discriminations between two small typographic characters are learned in the context of different visually complex scenes. In the present study, we examined whether neurotoxic lesions of ventrolateral prefrontal cortex in one hemisphere, combined with ablation of inferior temporal cortex in the contralateral hemisphere, would impair learning of new object-in-place scene problems. Male macaque monkeys learned 10 or 20 new object-in-place problems in each daily test session. Unilateral neurotoxic lesions of ventrolateral prefrontal cortex produced by multiple injections of a mixture of ibotenate and N-methyl-D-aspartate did not affect performance. However, when disconnection from inferotemporal cortex was completed by ablating this region contralateral to the neurotoxic prefrontal lesion, new learning was substantially impaired. Sham disconnection (injecting saline instead of neurotoxin contralateral to the inferotemporal lesion) did not affect performance. These findings support two conclusions: first, that the ventrolateral prefrontal cortex is a critical area within the frontal lobe for scene memory; and second, the effects of ablations of prefrontal cortex can be confidently attributed to the loss of cell bodies within the prefrontal cortex rather than to interruption of fibres of passage through the lesioned area.
机译：额叶与颞下皮质的分离导致许多认知任务的缺陷，这些任务需要将依赖记忆的规则应用于视觉刺激。在执行这些任务时与颞叶相互作用的额叶皮层的特定区域仍未定义。时空断开所削弱的一种能力是对新的现场物体场景问题的快速学习，其中在不同的视觉复杂场景的背景下学习了两个小的印刷字符之间的视觉辨别力。在本研究中，我们检查了一个半球腹外侧前额叶皮层的神经毒性损害，以及对侧半球下颞叶皮层的消融是否会损害对新的现场物体场景问题的学习。雄性猕猴在每个日常测试中会发现10或20个新的原位对象问题。多次注射依博替丁和N-甲基-D-天冬氨酸的混合物产生的腹侧前额叶皮层的单侧神经毒性损害不影响性能。然而，当通过消融与神经毒性前额叶病变对侧的该区域而完成与颞下皮质的分离时，新的学习将受到严重损害。假手术断开（在颞下病变的对侧注射生理盐水代替神经毒素）不会影响性能。这些发现支持两个结论：首先，腹侧前额叶皮层是额叶内场景记忆的关键区域;第二，前额叶皮质消融的影响可以肯定地归因于前额叶皮质内细胞体的损失，而不是归因于穿过病变区域的纤维的中断。

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