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首页> 外文期刊>The European Journal of Neuroscience >The effects of fear conditioning on cerebellar LTP and LTD.
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The effects of fear conditioning on cerebellar LTP and LTD.

机译：恐惧条件对小脑LTP和LTD的影响。

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Long-term potentiation (LTP) and depression (LTD) at parallel fibre-Purkinje cell synapses have been described in vitro in the cerebellar cortex, but the physiological roles of these two forms of plasticity have not been well defined. Here we show that, in cerebellar slices taken from rats that had undergone fear conditioning, there was a significant occlusion of electrically induced LTP at parallel fibre-Purkinje cell synapses. This effect was long-lasting and related to associative processes, as LTP was not occluded in unpaired animals. Notably, in conditioned animals the LTP-inducing protocol produced LTD in some cells instead of LTP. Conversely, synaptic depression induced by conjunctive stimulation of parallel fibers and climbing fibres was impaired in tissue taken immediately following aversive stimulation in both paired and unpaired subjects. This effect was not, however, long-lasting as the incidence and extent of LTD returned to normal levels 24 h after behavioural testing. These findings suggest that LTP takes part in the mechanisms underlying aversive associative memories in the cerebellum.
机译：在小脑皮层中已经描述了平行纤维-Purkinje细胞突触的长期增强（LTP）和抑制（LTD），但是尚不清楚这两种可塑性形式的生理作用。在这里，我们显示，在取自经历恐惧调节的大鼠的小脑切片中，平行纤维-浦肯野细胞突触上电诱导的LTP明显闭塞。这种作用是持久的，并且与缔合过程有关，因为在未配对的动物中不会阻塞LTP。值得注意的是，在条件动物中，LTP诱导方案在某些细胞中代替LTP产生LTD。相反，成对和不成对的受试者厌恶刺激后立即采集的组织中，平行纤维和攀爬纤维的联合刺激引起的突触抑制降低。然而，由于行为测试后24小时LTD的发生率和程度恢复到正常水平，因此这种作用不会持续很长时间。这些发现表明，LTP参与了小脑厌恶联想记忆的潜在机制。

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