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首页> 外文期刊>The European Journal of Neuroscience >Crossed cortico-spinal motor control after capsular stroke.
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Crossed cortico-spinal motor control after capsular stroke.

机译：囊状中风后交叉皮质脊髓运动控制。

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While it is widely accepted that multiple nonprimary motor areas such as the dorsal premotor cortex contribute to recovery from stroke, the contribution of the ipsilesional and contralesional primary motor cortex (M1) is controversial. It has been suggested that re-instating 'near normal' activation patterns is a good strategy for recovery of function [Baron et al., (2004) Cerebrovasc. Dis., 18, 260-267; Ward & Cohen, (2004) Arch. Neurol., 61, 1844-1848]. The present study addressed this aspect of stroke recovery by combining transcranial magnetic stimulation (TMS) and magnetoencephalography (MEG) in a cross-sectional design on nine patients with well-recovered motor function 17.6 +/- 5.5 months (mean +/- SD) after subcortical stroke. While TMS was applied to probe the integrity of the cortico-spinal tract (CST) at rest, MEG was used to test for recruitment of CST pathways during a motor challenge [cortico-muscular coherence (CMC) in a precision grip task]. With both techniques, crossed cortico-spinal connectivity could be demonstrated. A significant correlation (r = 0.85) of CMC magnitude and recovered muscle strength underlined the functional relevance of crossed CST integrity for successful recovery. In conclusion, at the descriptive level, crossed CST connectivity is a common finding in well-recovered patients with capsular stroke. This renders it likely that maintaining or regaining use of crossed CST fibers is one way to achieve effective recovery.
机译：尽管人们普遍认为多个非主要运动区域（例如背侧运动前皮层）有助于中风恢复，但同侧和对侧主要运动皮层（M1）的作用仍存在争议。已经提出，恢复“接近正常”的激活模式是恢复功能的良好策略[Baron et al。，（2004）Cerebrovasc。 Dis。，18，260-267;沃德和科恩（Ward＆Cohen），（2004年）拱门。神经病学，61，1844-1848]。本研究通过结合经颅磁刺激（TMS）和脑磁图（MEG）在9例运动功能良好的17.6 +/- 5.5个月（平均+/- SD）患者中进行横断面设计，解决了中风恢复的这一方面。皮质下中风后。虽然将TMS应用于探测静止时的皮质-脊髓（CST）的完整性，但MEG用于测试运动挑战中的CST通路的募集[精密抓握任务中的皮质-肌肉连贯性（CMC）]。两种技术都可以证明交叉的皮质-脊髓连接。 CMC大小与恢复的肌肉力量之间的显着相关性（r = 0.85）强调了交叉CST完整性对于成功恢复的功能相关性。总之，在描述性水平上，交叉CST连通性是在良好康复的囊膜中风患者中常见的发现。这使得保持或重新使用交叉的CST纤维成为实现有效恢复的一种方法。

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