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首页> 外文期刊>The European Journal of Neuroscience >Rhythmic auditory stimulation modulates gait variability in Parkinson's disease.
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Rhythmic auditory stimulation modulates gait variability in Parkinson's disease.

机译：有节奏的听觉刺激调节帕金森氏病的步态变异性。

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Patients with Parkinson's disease (PD) walk with a shortened stride length and high stride-to-stride variability, a measure associated with fall risk. Rhythmic auditory stimulation (RAS) improves stride length but the effects on stride-to-stride variability, a marker of fall risk, are unknown. The effects of RAS on stride time variability, swing time variability and spatial-temporal measures were examined during 100-m walks with the RAS beat set to 100 and 110% of each subject's usual cadence in 29 patients with idiopathic PD and 26 healthy age-matched controls. Carryover effects were also evaluated. During usual walking, variability was significantly higher (worse) in the patients with PD compared with the controls (P < 0.01). For the patients with PD, RAS at 100% improved gait speed, stride length and swing time (P < 0.02) but did not significantly affect variability. With RAS at 110%, reductions in variability were also observed (P < 0.03) and these effects persisted 2 and 15 min later. In the control subjects, the positive effects of RAS were not observed. For example, RAS increased stride time variability at 100 and 110%. These results demonstrate that RAS enables more automatic movement and reduces stride-to-stride variability in patients with PD. Further, these improvements are not simply a by-product of changes in speed or stride length. After walking with RAS, there also appears to be a carryover effect that supports the possibility of motor plasticity in the networks controlling rhythmicity in PD and the potential for using RAS as an intervention to improve mobility and reduce fall risk.
机译：帕金森氏病（PD）患者的步幅较短，步幅差异较大，这是一种与跌倒风险相关的措施。有节奏的听觉刺激（RAS）可改善步幅，但对步幅变异性（跌倒风险的标志）的影响尚不清楚。在29例特发性PD患者和26岁健康年龄的29岁患者中，在100 m的步行过程中检查了RAS对步幅时间变异性，摆动时间变异性和时空测量的影响匹配的控件。还评估了残留效应。在正常的步行过程中，PD患者的变异性明显比对照组高（更差）（P <0.01）。对于PD患者，RAS 100％改善步态速度，步幅和摆动时间（P <0.02），但并未显着影响变异性。 RAS为110％时，也观察到变异性降低（P <0.03），并且这些影响在2和15分钟后持续存在。在对照受试者中，未观察到RAS的积极作用。例如，RAS将步幅时间可变性提高了100％和110％。这些结果表明，RAS可使PD患者更自动地运动并降低步幅之间的差异。此外，这些改进不仅仅是速度或步幅变化的副产品。用RAS行走后，似乎还有一种残留效应，支持控制PD节律性的网络中运动可塑性的可能性，以及使用RAS作为干预措施以改善活动能力并降低跌倒风险的可能性。

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