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首页> 外文期刊>The European Journal of Neuroscience >Differential tonic influence of lateral habenula on prefrontal cortex and nucleus accumbens dopamine release.
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Differential tonic influence of lateral habenula on prefrontal cortex and nucleus accumbens dopamine release.

机译：侧唇对前额叶皮层和伏隔核多巴胺释放的影响。

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Conditions of increased cognitive or emotional demand activate dopamine release in a regionally selective manner. Whereas the brief millisecond response of dopamine neurons to salient stimuli suggests that dopamine's influence on behaviour may be limited to signalling certain cues, the prolonged availability of dopamine in regions such as the prefrontal cortex and nucleus accumbens is consistent with the well described role of dopamine in maintaining motivation states, associative learning and working memory. The behaviourally elicited terminal release of dopamine is generally attributed to increased excitatory drive on dopamine neurons. Our findings here, however, indicate that this increase may involve active removal of a tonic inhibitory control on dopamine neurons exerted by the lateral habenula (LHb). Inhibition of LHb in behaving animals transiently increased dopamine release in the prefrontal cortex, nucleus accumbens and dorsolateral striatum. The inhibitory influence was more pronounced in thenucleus accumbens and striatum than in the prefrontal cortex. This pattern of regional dopamine activation after LHb inhibition mimicked conditions of reward availability but not increased cognitive demand. Electrical or chemical stimulation of LHb produced minimal reduction of extracellular dopamine, suggesting that in an awake brain the inhibition associated with tonic LHb activity represents a near-maximal influence on dopamine neurotransmission. These data indicate that LHb may be critical for functional differences in dopamine neurons by preferentially modulating dopamine neurons that project to the nucleus accumbens over those neurons that primarily project to the prefrontal cortex.
机译：认知或情绪需求增加的条件以区域选择性方式激活多巴胺释放。尽管多巴胺神经元对显着刺激的短暂毫秒响应表明，多巴胺对行为的影响可能仅限于发出某些信号，但在前额叶皮层和伏隔核等区域，多巴胺的长期可用性与多巴胺在神经元中的良好作用相一致。保持动力状态，联想学习和工作记忆。行为引起的多巴胺最终释放通常归因于对多巴胺神经元的兴奋性驱动增加。但是，我们在这里的发现表明，这种增加可能涉及主动消除对外侧ha（LHb）施加的多巴胺神经元的强直抑制性控制。行为动物中LHb的抑制会短暂增加前额叶皮层，伏隔核和背外侧纹状体中多巴胺的释放。与伏前核相比，伏隔核和纹状体的抑制作用更为明显。 LHb抑制后，区域多巴胺激活的这种模式模仿了奖励可用性的条件，但并未增加认知需求。 LHb的电刺激或化学刺激产生的细胞外多巴胺减少量最小，这表明在清醒的大脑中，与补品LHb活性相关的抑制作用代表了对多巴胺神经传递的近乎最大的影响。这些数据表明，通过优先调节投射到伏隔核的多巴胺神经元，而不是主要投射到额叶前皮层的神经元，LHb对于多巴胺神经元的功能差异可能至关重要。

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