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首页> 外文期刊>The European Journal of Neuroscience >Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis.
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Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis.

机译：未成熟大鼠的癫痫持续状态导致行为和认知障碍以及癫痫发生。

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摘要

It remains under dispute whether status epilepticus (SE) in the perinatal period or early childhood or the underlying neuropathology is the cause of functional impairment later in life. The present study examined whether SE induced by LiCl-pilocarpine in normal immature brain (at the age of 12 or 25 days; P12 or P25) causes cognitive decline and epileptogenesis, and the data were compared to those of rats undergoing SE as adults. Rats in the P12 group had impaired memory (repeated exposure to open-field paradigm) and emotional behaviour (lower proportion of open-arm entries and higher incidence of risk assessment period in elevated plus-maze) when assessed 3 months after SE, although not as severe as in the older age groups. Importantly, video-electroencephalography monitoring 3 months after SE demonstrated that 25% of rats in the P12 and 50% in P25 group developed spontaneous seizures. Only nonconvulsive seizures (ictal activity in hippocampus accompanied by automatisms) were recorded in the P12 groupwhereas rats in the P25 group exhibited clonic convulsions. The present findings indicate that SE is harmful to the immature brain as early as P12, which might be compared with early infancy in humans.
机译：围产期或幼儿期的癫痫持续状态（SE）或潜在的神经病理学是否是生活后期功能障碍的原因，仍存在争议。本研究研究了在未成熟的正常大脑中（12或25天; P12或P25年龄），LiCl-毛果芸香碱诱导的SE是否引起认知能力下降和癫痫发生，并将数据与成年SE的大鼠进行了比较。在SE后3个月进行评估时，P12组的大鼠记忆力减退（重复暴露于开放视野范式）和情绪行为（张开双臂的比例降低，高迷宫中风险评估期的发生率较高），尽管没有和老年人一样严重。重要的是，SE后3个月的电视脑电图监测表明，P12组中有25％的大鼠和P25组中有50％的大鼠自发发作。在P12组中仅记录了非惊厥性癫痫发作（海马的发作活动并伴有自动性），而P25组中的大鼠表现出阵挛性惊厥。目前的发现表明SE早在P12时就对未成熟的大脑有害，这可以与人类的婴儿早期相提并论。

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