Theimpactofenvironmentalchangesuponthemicrorheologicalresponseofadherentcells

C.Picard; A.Donald

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Theimpactofenvironmentalchangesuponthemicrorheologicalresponseofadherentcells

机译：环境变化对粘附细胞微流变反应的影响

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Themechanicalbehaviourofadherentcellsculturedinvitroisknowntobedependentonthemechanicalpropertiesofthesubstrate.Weshowthatthismechanicalbehaviourisalsostronglyaectedbythecells’environment.WefocushereontheimpactoftemperatureandpH.Experimentscarriedoutonindividualcellsinatuneableenvironmentrevealthattheintra-cellularmechanicalbehaviourexhibitslargeandfastchangeswhentheexternalcellenvironmentischanged.Fastpassivemicrorheometrymeasurementsallowfortheprecisecharacterisationofthetransientregimeobservedduringatemperaturedrop.Whenmaintainedatanon-physiologicaltemperature,thecellsreachastabilisedstatedistinctfromthestateobservedinphysiologicalconditions.Theperturbationcanbereversedbutexhibitshystereticbehaviourwhenphysiologicalconditionsarerestored.Thetransientregimeobservedduringtherecoveryprocessisfoundtobedierentfromthetransientregimeobservedwhenleavingphysiologicalconditions.AmodiedgeneralizedStokes-Einsteinequationtakingintoaccountthecellactivitythroughaneectivetemperatureisproposedheretottheexperimentalresults.Excellentagreementbetweenthemodelandthemeasurementsisobtainedfortimelagsfrom103to1sconsideredinthisstudy.

机译：Themechanicalbehaviourofadherentcellsculturedinvitroisknowntobedependentonthemechanicalpropertiesofthesubstrate.Weshowthatthismechanicalbehaviourisalsostronglyaectedbythecells'environment.WefocushereontheimpactoftemperatureandpH.Experimentscarriedoutonindividualcellsinatuneableenvironmentrevealthattheintra-cellularmechanicalbehaviourexhibitslargeandfastchangeswhentheexternalcellenvironmentischanged.Fastpassivemicrorheometrymeasurementsallowfortheprecisecharacterisationofthetransientregimeobservedduringatemperaturedrop.Whenmaintainedatanon-physiologicaltemperature，thecellsreachastabilisedstatedistinctfromthestateobservedinphysiologicalconditions.Theperturbationcanbereversedbutexhibitshystereticbehaviourwhenphysiologicalconditionsarerestored.Thetransientregimeobservedduringtherecoveryprocessisfoundtobedierentfromthetransientregimeobservedwhenleavingphysiologicalconditions.AmodiedgeneralizedStokes-Einsteinequationtakingintoaccountthecellactivitythroughaneectivetemperatureisproposedheretot在本研究中，考虑到模式之间的时延，从103到1的时滞中得出了良好的测量结果。

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《The European physical journal, E. Soft matter》 |2009年第2期|共8页
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C.Picard; A.Donald;
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正文语种 eng
中图分类物理学;
关键词
properties; generalized; physiological;

机译：性质;广义;生理;

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1. Theimpactofenvironmentalchangesuponthemicrorheologicalresponseofadherentcells [J] . C.Picard, A.Donald The European physical journal, E. Soft matter . 2009,第2期

机译：环境变化对粘附细胞微流变反应的影响

Theimpactofenvironmentalchangesuponthemicrorheologicalresponseofadherentcells

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