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首页> 外文期刊>Chest: The Journal of Circulation, Respiration and Related Systems >Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9- to 12-year-old children.
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Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9- to 12-year-old children.

机译：9至12岁健康儿童的呼出气一氧化氮浓度受年龄，身高和种族的影响。

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BACKGROUND: The fractional concentration of exhaled nitric oxide (Feno) is a useful indicator of airway inflammation in children and adults with asthma. METHODS: We determined the range of Feno concentrations and the factors affecting it in a large sample of healthy school children attending grades 4 through 6, in Windsor, ON, Canada. RESULTS: Feno was measured in 657 children between 9.1 and 12.9 years of age. The range of Feno concentrations in healthy school children was 12.7 parts per billion (ppb) [95% confidence interval (CI), 11.8 to 13.7 ppb] in whites and 22.8 ppb [95% CI, 17.9 to 27.7 ppb] in Asian-Canadian children (p < 0.001). Feno values also appeared to be higher in African-Canadian children than in whites, although the CI was wide because of the small number of African-Canadian children sampled. Feno rose slightly but significantly with age (p = 0.007) and with height (p = 0.023). Body mass index and gender did not significantly alter the measured Feno. FVC had a nonsignificant effect onFeno. Participation in physical activity during the same day had a borderline-significant effect on measured Feno, but a reported history of a respiratory tract infection in the preceding 2 weeks did not. CONCLUSIONS: Feno concentrations in healthy school-aged children appeared to be affected by race, and, to a lesser extent, by age and height. These factors should be taken into consideration when interpreting clinical results.
机译：背景：呼出气一氧化氮（Feno）的分数浓度是哮喘儿童和成人气道炎症的有用指标。方法：我们在加拿大温莎市的4至6年级的健康学生的大量样本中确定了Feno浓度的范围及其影响因素。结果：Feno在9.1至12.9岁的657名儿童中进行了测量。健康学龄儿童中Feno的浓度范围是，白人为12.7十亿分之（ppb）[95％置信区间（CI），11.8至13.7 ppb]，亚洲-加拿大为22.8 ppb [95％CI，17.9至27.7 ppb]儿童（p <0.001）。非洲裔加拿大儿童的Feno值似乎也高于白人，尽管由于抽样的非洲裔加拿大儿童数量少，CI范围也较宽。 Feno随年龄（p = 0.007）和身高（p = 0.023）而略微但显着上升。体重指数和性别没有显着改变测得的Feno。 FVC对Feno的影响不显着。当天参加体育锻炼对Feno的测量值具有明显的临界影响，但前2周的呼吸道感染史没有报道。结论：健康学龄儿童中的Feno浓度似乎受到种族的影响，并且在较小程度上受年龄和身高的影响。解释临床结果时应考虑这些因素。

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