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首页> 外文期刊>The East African medical journal >Correlation of clinical data, anatomical site and disease stage in colorectal cancer.
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Correlation of clinical data, anatomical site and disease stage in colorectal cancer.

机译：大肠癌的临床数据，解剖部位和疾病分期的相关性。

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OBJECTIVE: To evaluate the colorectal cancer clinical data with respect to the anatomical location and stage of disease. DESIGN: Retrospective observational study. SETTING: Kenyatta National Hospital (KNH), Nairobi, Kenya. SUBJECTS: Two hundred and fifty three tumours were categorised as right colonic (RCC), left colonic (LCC) and rectal (RC) lesions. The distribution of symptoms (rectal bleeding, tenesmus, change in bowel habits, abdominal pain, intestinal obstruction, rectal mass), anaemia, transfusion requirement, and the Dukes' stages were compared for right colon, left colon and rectal tumours. RESULTS: There were 54 RCC, 59 LCC, 140 RC lesions. Patient delay from onset of symptom(s) to presentation was a mean of 26.6 +/- 43, 20 +/- 25 and 33.7 +/- 42 weeks for right, left and rectal lesions respectively (p = 0.092). The proportion of patients presenting with rectal bleeding was 21%, 44% and 79% for RCC, LCC and RC lesions, respectively. The prevalence of intestinal obstruction was 14.8%, 27.1% and 43.6% in right, left and rectal lesions, respectively. The haemoglobin levels were significantly lower for right sided lesions (p = 0.05 for right colon/rectum pair; p = 0.059 for right colon/left colon pair). The sites of the lesions had no relationship to the stage of disease at presentation. CONCLUSION: In patients with colorectal cancer, the duration of symptoms was prolonged irrespective of the anatomical sub-sites. Symptoms were evenly distributed across the anatomical regions except for bleeding and obstruction which predominated in rectal and left colon cancers respectively. This underlines the need for early investigations in patients with rectal bleeding, change of bowel habit, intestinal obstruction and anaemia.
机译：目的：从疾病的解剖位置和阶段评估大肠癌的临床数据。设计：回顾性观察研究。地点：肯尼亚内罗毕肯雅塔国家医院（KNH）。研究对象：253个肿瘤分为右结肠癌（RCC），左结肠癌（LCC）和直肠癌（RC）。比较右结肠，左结肠和直肠肿瘤的症状分布（直肠出血，里急后重，排便习惯改变，腹痛，肠梗阻，直肠肿块），贫血，输血需求和Dukes分期。结果：共有54个RCC，59个LCC，140个RC病变。从症状发作到表现的患者延迟分别为右，左和直肠病变的平均26.6 +/- 43、20 +/- 25和33.7 +/- 42周（p = 0.092）。对于RCC，LCC和RC病变，直肠出血患者的比例分别为21％，44％和79％。右，左和直肠病变的肠梗阻患病率分别为14.8％，27.1％和43.6％。右侧病变的血红蛋白水平显着降低（右侧结肠/直肠对p = 0.05;右侧结肠/左结肠对p = 0.059）。病变的部位与呈现时的疾病阶段无关。结论：在大肠癌患者中，症状的持续时间延长，而与解剖部位无关。除出血和阻塞分别在直肠癌和左结肠癌中占主导地位外，症状在整个解剖区域均匀分布。这强调了对直肠出血，大便习惯改变，肠梗阻和贫血患者进行早期检查的必要性。

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