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首页> 外文期刊>The Canadian journal of cardiology >Daily low-dose folic acid supplementation does not prevent nitroglycerin-induced nitric oxide synthase dysfunction and tolerance: a human in vivo study.
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Daily low-dose folic acid supplementation does not prevent nitroglycerin-induced nitric oxide synthase dysfunction and tolerance: a human in vivo study.

机译：每日低剂量叶酸补充剂不能预防硝酸甘油诱导的一氧化氮合酶功能障碍和耐受性：一项人体体内研究。

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INTRODUCTION: Continuous treatment with nitroglycerin (GTN) causes tolerance and endothelial dysfunction, both of which may involve endothelial nitric oxide synthase (eNOS) dysfunction. eNOS dysfunction may be linked to depletion of tetrahydrobiopterin, and folic acid may be involved in the regeneration of this cofactor. It has been demonstrated that 10 mgday folic acid supplementation prevents the development of GTN tolerance and GTN-induced endothelial dysfunction. However, the efficacy of daily lower-dose folic acid supplementation for preventing these phenomena has not been investigated. OBJECTIVE: To determine the effect of 1 mgday folic acid supplementation on responses to sustained GTN therapy. METHODS AND RESULTS: On visit 1, 20 healthy male volunteers were randomly assigned to receive either oral folic acid (1 mgday) or placebo for one week in a double- blind study. All subjects also received continuous transdermal GTN (0.6 mgh). On visit 2, forearm blood flow was measured using venous occlusion strain-gauge plethysmography in response to incremental intra-arterial infusions of acetylcholine, N-monomethyl-L-arginine and GTN. Subjects in both groups displayed significantly decreased responses to acetylcholine and N-monomethyl-L-arginine infusions compared with a control group that received no treatment. Responses to GTN were also significantly diminished in both groups (P<0.05 for all). DISCUSSION: The present data demonstrate that daily supplementation with 1 mg folic acid does not prevent the development of GTN-induced eNOS dysfunction or tolerance.
机译：简介：硝酸甘油（GTN）持续治疗会引起耐受性和内皮功能障碍，这两者都可能涉及内皮型一氧化氮合酶（eNOS）功能障碍。 eNOS功能障碍可能与四氢生物蝶呤的消耗有关，而叶酸可能参与该辅因子的再生。已经证实，补充10mgday的叶酸可以防止GTN耐受性的发展和GTN诱导的内皮功能障碍。但是，尚未研究每日补充小剂量叶酸预防这些现象的功效。目的：确定1 mgday叶酸补充对持续GTN治疗反应的影响。方法和结果：在第1次就诊时，在双盲研究中，随机分配20名健康的男性志愿者接受口服叶酸（1毫克/天）或安慰剂治疗一周。所有受试者还接受了连续透皮GTN（0.6 mgh）。在第2次就诊时，使用静脉阻塞应变片体积描记法测量前臂血流量，以响应动脉内逐渐注入乙酰胆碱，N-单甲基-L-精氨酸和GTN。与未接受治疗的对照组相比，两组受试者对乙酰胆碱和N-单甲基-L-精氨酸输注的反应均明显降低。两组的对GTN的反应也显着降低（所有P均<0.05）。讨论：目前的数据表明，每天补充1 mg叶酸并不能阻止GTN诱导的eNOS功能障碍或耐受性的发展。

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