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首页> 外文期刊>The FEBS journal >Peroxisome proliferator-activated receptor alpha plays a vital role in inducing a detoxification system against plant compounds with crosstalk with other xenobiotic nuclear receptors
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Peroxisome proliferator-activated receptor alpha plays a vital role in inducing a detoxification system against plant compounds with crosstalk with other xenobiotic nuclear receptors

机译：过氧化物酶体增殖物激活受体α在诱导对植物化合物的排毒系统中具有与其他异种核受体的串扰作用中至关重要

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摘要

Peroxisome proliferator-activated receptor alpha (PPARalpha) is thought to play an important role in lipid metabolism in the liver. To clarify the extra-hepatic and/or unknown function of PPARalpha, we previously performed a proteome analysis of the intestinal proteins and identified 17beta-hydroxysteroid dehydrogenase type 11 as a mostly induced protein by a PPARalpha ligand [Motojima, K. (2004) Eur. J. Biochem. 271, 4141-4146]. Because of its supposed wide substrate specificity, we examined the possibility that PPARalpha plays an important role in inducing detoxification systems for some natural foods by feeding mice with various plant seeds and grains. Feeding with sesame but not others often killed PPARalpha knockout mice but not wild-type mice. A microarray analysis of the sesame-induced mRNAs in the intestine revealed that PPARalpha plays a vital role in inducing various xenobiotic metabolizing enzymes in the mouse intestine and liver. A PPARalpha ligand alone could not induce most of these enzymes, suggesting that there is an essential crosstalk among PPARalpha and other xenobiotic nuclear receptors to induce a detoxification system for plant compounds.
机译：过氧化物酶体增殖物激活受体α（PPARalpha）被认为在肝脏脂质代谢中起重要作用。为了阐明PPARalpha的肝外功能和/或未知功能，我们先前对肠道蛋白进行了蛋白质组分析，并确定了17β-羟类固醇脱氢酶11型是PPARalpha配体的主要诱导蛋白[Motojima，K.（2004）Eur 。 J.生物化学。 271，4141-4146]。由于其假定的广泛的底物特异性，我们检查了PPARalpha通过为小鼠喂食各种植物种子和谷物而在诱导某些天然食品的解毒系统中起重要作用的可能性。用芝麻而不是其他饲料喂养通常会杀死PPARalpha基因敲除小鼠，但不会杀死野生型小鼠。对芝麻在肠中的mRNA进行的微阵列分析显示，PPARalpha在诱导小鼠肠和肝中各种异源生物代谢酶中起着至关重要的作用。单独的PPARalpha配体不能诱导大多数这些酶，这表明PPARalpha与其他异源核受体之间存在必不可少的串扰，以诱导植物化合物的解毒系统。

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