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首页> 外文期刊>The FEBS journal >Epigenetic regulation of endothelial-cell-mediated vascular repair
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Epigenetic regulation of endothelial-cell-mediated vascular repair

机译：内皮细胞介导的血管修复的表观遗传调控

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摘要

Maintenance of vascular integrity is essential for the prevention of vascular disease and for recovery following cardiovascular, cerebrovascular and peripheral vascular events including limb ischemia, heart attack and stroke. Endothelial stem/progenitor cells have recently gained considerable interest due to their potential use in stem cell therapies to mediate revascularization after ischemic injury. Therefore, there is an urgent need to understand fundamental mechanisms regulating vascular repair in specific cell types to develop new beneficial therapeutic interventions. In this review, we highlight recent studies demonstrating that epigenetic mechanisms (including post-translational modifications of DNA and histones as well as non-coding RNA-mediated processes) play essential roles in the regulation of endothelial stem/progenitor cell functions through modifying chromatin structure. Furthermore, we discuss the potential of using small molecules that modulate the activities of epigenetic enzymes to enhance the vascular repair function of endothelial cells and offer insight on potential strategies that may accelerate clinical applications.
机译：维持血管完整性对于预防血管疾病以及心血管，脑血管和周围血管事件（包括肢体缺血，心脏病和中风）后的康复至关重要。内皮干/祖细胞由于其在干细胞治疗中介导缺血性损伤后血管再生的潜在用途而引起了人们的极大兴趣。因此，迫切需要了解调节特定细胞类型中的血管修复的基本机制，以开发新的有益的治疗干预措施。在这篇综述中，我们重点介绍了最近的研究，这些研究表明表观遗传机制（包括DNA和组蛋白的翻译后修饰以及非编码RNA介导的过程）在通过修饰染色质结构调节内皮干细胞/祖细胞功能中起着至关重要的作用。 。此外，我们讨论了使用小分子来调节表观遗传酶的活性以增强内皮细胞的血管修复功能的潜力，并提供了可能加速临床应用的潜在策略的见解。

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