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首页> 外文期刊>The FEBS journal >The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts
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The importance of polymerization and galloylation for the antiproliferative properties of procyanidin-rich natural extracts

机译：聚合和没食子酸酯化对富含原花青素的天然提取物的抗增殖性能的重要性

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摘要

Grape (Vitis vinifera) and pine (Pinus pinaster) bark extracts are widely used as nutritional supplements. Procyanidin-rich fractions from grape and pine bark extract showing different mean degrees of polymerization, percentage of galloylation (percentage of gallate esters) and reactive oxygen species-scavenging capacity were tested on HT29 human colon cancer cells. We observed that the most efficient fractions in inhibiting cell proliferation, arresting the cell cycle in G(2) phase and inducing apoptosis were the grape fractions with the highest percentage of galloylation and mean degree of polymerization. Additionally, the antiproliferative effects of grape fractions were consistent with their oxygen radical-scavenging capacity and their ability to trigger DNA condensation-fragmentation.
机译：葡萄（Vitis vinifera）和松树（Pinus pinaster）树皮提取物被广泛用作营养补品。在HT29人结肠癌细胞上测试了来自葡萄和松树皮提取物的富含原花青素的馏分，这些馏分显示出不同的平均聚合度，没食子酸酯化的百分比（没食子酸酯的百分比）和清除活性氧的能力。我们观察到，抑制细胞增殖，阻滞G（2）期细胞周期并诱导凋亡的最有效馏分是具有最高胆甾醇化率和平均聚合度的葡萄馏分。此外，葡萄馏分的抗增殖作用与其清除氧自由基的能力和引发DNA缩合碎片的能力相一致。

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