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首页> 外文期刊>The FEBS journal >Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily.
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Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily.

机译：人组氨酸三联体核苷酸结合蛋白2（组氨酸三联体超家族成员）的结构特征。

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摘要

The histidine triad proteins (HITs) constitute a large and ubiquitous superfamily of nucleotide hydrolases. The human histidine triad nucleotide-binding proteins (hHints) are a distinct class of HITs noted for their acyl-AMP hydrolase and phosphoramidase activity. The first high-resolution crystal structures of hHint2 with and without bound AMP are described. The differences between hHint2 and previously known HIT family protein structures are discussed. HIT family enzymes have historically been divided into five classes based on their catalytic specificity: Hint, fragile HIT protein, galactose-1-phosphate uridylyltransferase, DcpS and aprataxin. However, although several structures exist for the enzymes in these classes, the endogenous substrates of many of these enzymes have not been identified or biochemically characterized. To better understand the structural relationships of the HIT enzymes, a structure-based phylogeny was constructed that resulted in the identification of several new putative HIT clades with potential acyl-AMP hydrolase and phosphoramidase activity. 2013 FEBS.Registry Number/Name of Substance 0 (Hint2 protein, human). 0 (Mitochondrial Proteins). 61-19-8 (Adenosine Monophosphate).
机译：组氨酸三联体蛋白（HIT）构成了核苷酸水解酶的一个大而普遍的超家族。人组氨酸三联体核苷酸结合蛋白（hHints）是一类独特的HIT，它们以其酰基AMP水解酶和磷酸酰胺酶的活性着称。描述了有和没有结合AMP的hHint2的第一个高分辨率晶体结构。讨论了hHint2和以前已知的HIT家族蛋白结构之间的差异。 HIT系列酶历来根据其催化特异性分为五类：提示，脆弱的HIT蛋白，半乳糖1-磷酸尿嘧啶转移酶，DcpS和紫杉醇。然而，尽管这些类别的酶存在几种结构，但是许多这些酶的内源底物尚未被鉴定或生物化学表征。为了更好地了解HIT酶的结构关系，构建了基于结构的系统发育系统，从而鉴定了一些具有潜在酰基AMP水解酶和磷酸酰胺酶活性的新的HIT进化枝。 2013年FEBS，注册号/物质0的名称（Hint2蛋白，人类）。 0（线粒体蛋白）。 61-19-8（单磷酸腺苷）。

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