...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The FEBS journal >Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity
【24h】

Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity

机译：多功能宿主防御肽：抗菌肽，先天性和适应性免疫的规模较小而规模较大

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The term 'antimicrobial peptides' refers to a large number of peptides first characterized on the basis of their antibiotic and antifungal activities. In addition to their role as endogenous antibiotics, antimicrobial peptides, also called host defense peptides, participate in multiple aspects of immunity (inflammation, wound repair, and regulation of the adaptive immune system) as well as in maintaining homeostasis. The possibility of utilizing these multifunctional molecules to effectively combat the ever-growing group of antibiotic-resistant pathogens has intensified research aimed at improving their antibiotic activity and therapeutic potential, without the burden of an exacerbated inflammatory response, but conserving their immunomodulatory potential. In this minireview, we focus on the contribution of small cationic antimicrobial peptides - particularly human cathelicidins and defensins - to the immune response and disease, highlighting recent advances in our understanding of the roles of these multifunctional molecules.
机译：术语“抗微生物肽”是指首先基于其抗生素和抗真菌活性而表征的大量肽。除其作为内源性抗生素的作用外，抗菌肽（也称为宿主防御肽）还参与免疫的多个方面（炎症，伤口修复和适应性免疫系统的调节）以及维持体内平衡。利用这些多功能分子有效地对抗不断增长的抗生素抗性病原体的可能性已经加强了旨在改善其抗生素活性和治疗潜能的研究，而没有加剧炎症反应的负担，却保留了其免疫调节潜能。在本小型审查中，我们重点研究小型阳离子抗微生物肽（尤其是人cathelicidins和防御素）对免疫反应和疾病的贡献，强调我们对这些多功能分子的作用的最新进展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号