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首页> 外文期刊>The FEBS journal >MicroRNAs and the regulation of fibrosis. [Review] [46 refs]
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MicroRNAs and the regulation of fibrosis. [Review] [46 refs]

机译：MicroRNA和纤维化的调节。 [评论] [46裁判]

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摘要

MicroRNAs (miRNAs) are small, noncoding RNAs of 18-25 nucleotides that are generally believed to either block the translation or induce the degradation of target mRNA. miRNAs have been shown to play fundamental roles in diverse biological and pathological processes, including cell proliferation, differentiation, apoptosis and carcinogenesis. Fibrosis results from an imbalance in the turnover of extracellular matrix molecules and is a highly debilitating process that can eventually lead to organ dysfunction. A growing body of evidence suggests that miRNAs participate in the fibrotic process in a number of organs including the heart, kidney, liver and lung. In this review, we summarize our current understanding of the role of miRNAs in the development of tissue fibrosis and their potential as novel drug targets. [References: 46]
机译：MicroRNA（miRNA）是18-25个核苷酸的小型非编码RNA，通常认为它们会阻断翻译或诱导目标mRNA降解。 miRNA已显示在多种生物学和病理学过程中起基本作用，包括细胞增殖，分化，凋亡和致癌作用。纤维化是由细胞外基质分子的代谢失衡导致的，是高度虚弱的过程，最终可能导致器官功能障碍。越来越多的证据表明，miRNA参与心脏，肾脏，肝脏和肺等许多器官的纤维化过程。在这篇综述中，我们总结了我们目前对miRNA在组织纤维化发展中的作用及其作为新型药物靶标的潜力的理解。 [参考：46]

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