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Missed opportunities in crystallography

机译:晶体学机会错失

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摘要

Scrutinized from the perspective of time, the giants in the history of crystallography more than once missed a nearly obvious chance to make another great discovery, or went in the wrong direction. This review analyzes such missed opportunities focusing on macromolecular crystallographers (using Perutz, Pauling, Franklin as examples), although cases of particular historical (Kepler), methodological (Laue, Patterson) or structural (Pauling, Ramachandran) relevance are also described. Linus Pauling, in particular, is presented several times in different circumstances, as a man of vision, oversight, or even blindness. His example underscores the simple truth that also in science incessant creativity is inevitably connected with some probability of fault.
机译:从时间的角度审视晶体学史上的巨人们一次又一次地错失了一次几乎显而易见的机会来进行另一个伟大的发现,或者走错了方向。这篇综述分析了这种错失的机会,主要针对大分子晶体学家(以佩鲁茨,鲍林,富兰克林为例),尽管也描述了与特定历史(开普勒),方法论(劳厄,帕特森)或结构(鲍林,拉马尚德)相关的案例。尤其是莱纳斯·鲍林(Linus Pauling),他多次出现在不同的情况下,都是一个有远见,疏忽甚至失明的人。他的例子强调了一个简单的事实,即在科学中,持续不断的创造力也不可避免地与某种过失的可能性有关。

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