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首页> 外文期刊>Biomaterials Science >3D printed tricalcium phosphate bone tissue engineering scaffolds: effect of SrO and MgO doping on in vivo osteogenesis in a rat distal femoral defect model
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3D printed tricalcium phosphate bone tissue engineering scaffolds: effect of SrO and MgO doping on in vivo osteogenesis in a rat distal femoral defect model

机译：3D打印磷酸三钙骨组织工程支架：SrO和MgO掺杂对大鼠股骨远端缺损模型体内成骨的影响

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摘要

The presence of interconnected macro pores is important in tissue engineering scaffolds for guided tissue regeneration. This study reports in vivo biological performance of interconnected macro porous tricalcium phosphate (TCP) scaffolds due to the addition of SrO and MgO as dopants in TCP. We have used direct three dimensional printing (3DP) technology for scaffold fabrication followed by microwave sintering. Mechanical strength was evaluated for scaffolds with 500 μm, 750 μm, and 1000 μm interconnected designed pore sizes. Maximum compressive strength of 12.01 ± 1.56 MPa was achieved for Sr-Mg doped scaffold with 500 μm interconnected designed pore size. In vivo biological performance of the microwave sintered pure TCP and Sr-Mg doped TCP scaffolds was assessed by implanting 350 μm designed interconnected macro porous scaffolds in rat distal femoral defect. Sintered pore size of these 3D printed scaffolds were 311 ± 5.9 μm and 245 ± 7.5 μm for pure and SrO-MgO doped TCP scaffolds, respectively. These 3D printed scaffolds possessed multiscale porosity, i.e., 3D interconnected designed macro pores along with intrinsic micro pores. Histomorphology and histomorphometric analysis revealed a significant increase in osteoid like new bone formation, and accelerated mineralization inside SrO and MgO doped 3D printed TCP scaffolds as compared to pure TCP scaffolds. An increase in osteocalcin and type I collagen level was also observed in rat blood serum with SrO and MgO doped TCP scaffolds compared to pure TCP scaffolds. Our results show that these 3D printed SrO and MgO doped TCP scaffolds with multiscale porosity contributed to early healing through accelerated osteogenesis.
机译：相互连接的大孔的存在在用于引导组织再生的组织工程支架中很重要。这项研究报告了互连的多孔磷酸三钙（TCP）互连支架的体内生物学性能，这是由于在TCP中添加了SrO和MgO作为掺杂剂。我们已经使用直接三维印刷（3DP）技术制造支架，随后进行微波烧结。对互连的设计孔径为500μm，750μm和1000μm的脚手架的机械强度进行了评估。具有500μm互连设计孔径的Sr-Mg掺杂支架的最大抗压强度达到12.01±1.56 MPa。微波烧结的纯TCP和Sr-Mg掺杂的TCP支架的体内生物学性能是通过在大鼠股骨远端缺损中植入350μm设计的互连的宏观多孔支架来评估的。这些3D打印支架的烧结孔尺寸分别为纯掺杂和SrO-MgO掺杂的TCP支架，分别为311±5.9μm和245±7.5μm。这些3D打印的支架具有多尺度的孔隙度，即3D互连设计的大孔以及固有的微孔。组织形态学和组织形态计量学分析显示，与纯TCP支架相比，类骨质明显增加，如新的骨骼形成，并且SrO​​和MgO掺杂的3D打印TCP支架内部加速矿化。与纯TCP支架相比，SrO和MgO掺杂的TCP支架在大鼠血清中也观察到骨钙素和I型胶原蛋白水平的增加。我们的结果表明，这些3D打印的SrO和MgO掺杂的TCP支架具有多尺度的孔隙度，可通过促进成骨作用促进早期愈合。

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