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首页> 外文期刊>Chinese journal of physiological sciences >CALCIUM CHANNEL AND ITS PHARMACOLOGICAL PROPERTIES IN MOTOR NERVE TERMINALS OF SNAKES
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CALCIUM CHANNEL AND ITS PHARMACOLOGICAL PROPERTIES IN MOTOR NERVE TERMINALS OF SNAKES

机译：蛇的运动神经末梢中的钙离子通道及其药理性质

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摘要

The characteristics of Ca~(2+) channels in snake motor nerve terminals of the transverses abdominis muscle of snakes (Elapke dione) were studied by using subendothe-lial recording. The results are as follows. (1) In medium containing 300 mu mol/L 3,4-diaminopyridine (3,4-DAP) or 10 mmol/L tetraethylammonium (TEA), Ca~(2+) current (I_(Ca)) was a sharp positive peak and relatively insensitive to stimulation frequency (<1 Hz). A slow component of I_(Ca), could be revealed by addition of both TEA and 3,4-DAP, which was more sensitive to stimulation frequency, i.e. 10 Hz stimulation would suppress almost all I_(Ca)- (2) I_(Ca) was far more sensitive to Cd~(2+) than to Ni~(2+) or Co~(2+) Verapamil (40 mu mol/L), nifedipine (10 mu mol/L) or BayK 8644 (10 mu mol/L) had no effect. However, all terminal currents including Na~+ current (I_(Na)) could be blocked by 80 mu mol/L nifedipine. (3) 2 mu mol/L omega-conotoxin GVIA irreversibly blocked I_(Ca) (4) 0.5 mmol/L Co~(2+) eliminated endplate potential (EPP)in 5 min. The effect was reversible. Cd~(2+) (100 mu mol/L), Ni~(2+) (0.5 mmol/L) or omega-conotoxin GVIA (1 mu mol/L) also blocked EPP, whereas verapamil (40 mu mol/L), nifedipine (20 mu mol/L) or BayK 8644 (20 mu mol/L) had no effect. The above resultsindicate that Ca~(2+) channels in snake motor nerve terminals were mainly composed of one type of Ca channel, with pharmacological characteristics pertaining to N type channel.
机译：利用内皮下记录法研究了蛇腹腹肌（Elapke dione）蛇运动神经末梢Ca〜（2+）通道的特征。结果如下。 （1）在含有300μmol/ L 3,4-二氨基吡啶（3,4-DAP）或10 mmol / L四乙铵（TEA）的介质中，Ca〜（2+）电流（I_（Ca））呈明显的正值峰值，对刺激频率（<1 Hz）相对不敏感。 I_（Ca）的缓慢成分可以通过添加TEA和3,4-DAP来揭示，这对刺激频率更加敏感，即10 Hz刺激会抑制几乎所有I_（Ca）-（2）I_（ Ca）对Cd〜（2+）的敏感性比对Ni〜（2+）或Co〜（2+）维拉帕米（40μmol / L），硝苯地平（10μmol / L）或BayK 8644（10 μmol / L）无效。然而，包括Na〜+电流（I_（Na））在内的所有终端电流都可以被80μmol / L的硝苯地平阻滞。 （3）2μmol / Lω-芋螺毒素GVIA不可逆地阻断了I_（Ca）（4）0.5 mmol / L Co〜（2+）在5分钟内消除了终板电位（EPP）。效果是可逆的。 Cd〜（2+）（100 mu mol / L），Ni〜（2+）（0.5 mmol / L）或ω-芋螺毒素GVIA（1 mu mol / L）也阻止EPP，而维拉帕米（40 mu mol / L） ），硝苯地平（20μmol/ L）或BayK 8644（20μmol/ L）无效。以上结果表明蛇运动神经末梢的Ca〜（2+）通道主要由一种Ca通道组成，其药理特性属于N型通道。

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