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首页> 外文期刊>Biomaterials Science >Drug loaded multilayered gold nanorods for combined photothermal and chemotherapy
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Drug loaded multilayered gold nanorods for combined photothermal and chemotherapy

机译：载药多层金纳米棒用于光热和化学疗法的联合

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In this study, gold nanorods (AuNRs) were first stabilized by hexadecyltrimethylammonium bromide (CTAB) and then coated with two kinds of polyelectrolytes (PE) and BSA to obtain multi-layered AuNRs (AuNRs-PE-BSA). Furthermore, the anti-cancer drug doxorubicin (DOX) was encapsulated into AuNRs-PE-BSA by the electrostatic force and the nanocomposites formed were named AuNRs/DOX-PE-BSA. The success of coating was verified by transmission electron microscopy (TEM), zeta potential, gel-electrophoresis and thermogravimetric analysis (TGA). The MTT assay indicated that the cytotoxicity of AuNRs decreased dramatically after multi-layer capping. The time-dependent nucleus-targeting capability of AuNRs/DOX-PE-BSA was confirmed in cell affinity evaluations. The in vitro and in vivo experiments demonstrated that AuNRs/DOX-PE-BSA, which combined photothermal and chemotherapy for tumor therapy, bears a markedly improved curative effect and holds promising prospects in the field of nanomedicine.
机译：在这项研究中，金纳米棒（AuNRs）首先用十六烷基三甲基溴化铵（CTAB）稳定，然后用两种聚电解质（PE）和BSA涂覆以获得多层AuNRs（AuNRs-PE-BSA）。此外，通过静电力将抗癌药阿霉素（DOX）封装到AuNRs-PE-BSA中，形成的纳米复合材料称为AuNRs / DOX-PE-BSA。涂层的成功通过透射电子显微镜（TEM），ζ电位，凝胶电泳和热重分析（TGA）进行了验证。 MTT分析表明，多层盖膜后，AuNRs的细胞毒性显着降低。在细胞亲和力评估中证实了AuNRs / DOX-PE-BSA的时间依赖性核靶向能力。体外和体内实验表明，结合光热和化学疗法用于肿瘤治疗的AuNRs / DOX-PE-BSA具有显着改善的疗效，在纳米医学领域具有广阔的前景。

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