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首页> 外文期刊>The British Journal of Nutrition >Effects of high-calcium diets with different whey proteins on weight loss and weight regain in high-fat-fed C57BL/6J mice
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Effects of high-calcium diets with different whey proteins on weight loss and weight regain in high-fat-fed C57BL/6J mice

机译：不同乳清蛋白高钙饮食对高脂喂养C57BL / 6J小鼠体重减轻和体重恢复的影响

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The aim of the study was to compare the effect of different whey protein-containing high-Ca diets on weight loss and weight regain in a model of diet-induced obesity. Obesity was induced in C57BL/6J mice with a high-fat (60 % of energy) diet. Weight loss by energy restriction was performed on four different high-Ca diets (1p"8 % CaCO3) containing different whey proteins (18 % of energy): l-lactalbumin (ALA), o-lactoglobulin (BLG), lactoferrin (LF) and whey protein isolate (WPI). After 7 weeks of energy restriction some of the mice were killed and the rest were fed with the same diets ad libitum for 7 weeks. The mice on the LF diet lost significantly more weight than mice on the WPI diet. The body fat content in the ALA and LF groups was significantly lower than in the WPI group (P < 0p"05) and the LF group differed significantly even from the BLG group (P < 0p"05). Ad libitum feeding after weight loss resulted in weight regain in all groups and only the ALA diet significantly reduced fat accumulation during weight regain. The weight regain was most pronounced in the LF group, but the adipocyte size was still significantly smaller than in the other groups. There were no differences in food intake or apparent fat digestibility between the groups. It can be concluded that a high-Ca diet with ALA significantly improves the outcome of weight loss and subsequent weight regain during the feeding of a high-fat diet in C57BL/6J mice, in comparison with WPI.
机译：该研究的目的是在饮食引起的肥胖症模型中比较不同的含乳清蛋白的高钙饮食对减肥和体重恢复的影响。在高脂（60％能量）饮食的C57BL / 6J小鼠中诱发了肥胖。通过能量限制对包含不同乳清蛋白（能量占18％）的四种不同的高钙饮食（1p“ 8％CaCO3）进行减肥：l-乳清蛋白（ALA），邻-乳球蛋白（BLG），乳铁蛋白（LF）能量限制7周后，杀死了部分小鼠，其余的小鼠则随意饲喂相同的饮食7周，LF饮食的小鼠比WPI的小鼠体重明显减轻饮食：ALA和LF组的体内脂肪含量明显低于WPI组（P <0p“ 05），而LF组甚至与BLG组也有显着差异（P <0p” 05）。体重减轻使所有组的体重均得到恢复，只有ALA饮食显着减少了体重减轻过程中的脂肪蓄积; LF组的体重恢复最为明显，但脂肪细胞的大小仍显着小于其他组。食物摄入量或表观脂肪消化率的差异组之间的y。可以得出结论，与WPI相比，在C57BL / 6J小鼠中高脂饮食喂养期间，ALA高钙饮食显着改善了体重减轻的结果和随后的体重恢复。

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