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首页> 外文期刊>The British Journal of Nutrition >Effect of the fat composition of a single high-fat meal on inflammatory markers in healthy young women.
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Effect of the fat composition of a single high-fat meal on inflammatory markers in healthy young women.

机译：单一高脂膳食的脂肪成分对健康年轻女性的炎症指标的影响。

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The aim of the present study was to examine the effect of a single high-fat meal with different fat quality on circulating inflammatory markers and gene expression in peripheral blood mononuclear cells (PBMC) to elucidate the role of fat quality on postprandial inflammation. A postprandial study with fourteen healthy females consuming three test meals with different fat quality was performed. Test days were separated by 2 weeks. Fasting and postprandial blood samples at 3 and 6 h after intake were analysed. The test meal consisted of three cakes enriched with coconut fat (43% energy as saturated fat and 1% energy as alpha-linolenic acid (ALA)), linseed oil (14% energy as ALA and 30% energy as saturated fat) and cod liver oil (5% energy as EPA and DHA and 5% energy as ALA in addition to 31% energy as saturated fat). In addition, ex vivo PBMC experiments were performed in eight healthy subjects investigating the effects of EPA and ALA on release and gene expression of inflammatory markers. The IL-8 mRNA level was significantly increased after intake of the cod liver oil cake at 6 h compared with fasting level, which was significantly different from the effect observed after the intake of linseed cake. In contrast, no effect was seen on circulating level of IL-8. In addition, ALA and EPA were shown to elicit different effects on the release and mRNA expression levels of inflammatory markers in PBMC cultured ex vivo, with EPA having the most prominent pro-inflammatory potential
机译：本研究的目的是研究一种具有不同脂肪质量的高脂膳食对循环炎症标志物和外周血单个核细胞（PBMC）中基因表达的影响，以阐明脂肪质量在餐后炎症中的作用。餐后研究对14名健康女性食用了三份不同脂肪质量的测试餐进行了研究。测试天数相隔2周。分析摄入后3和6小时的空腹和餐后血样。测试餐由三块蛋糕组成，这些蛋糕富含椰子脂（43％的能量为饱和脂肪，1％的能量为α-亚麻酸（ALA）），亚麻子油（14％的能量为ALA，30％的能量为饱和脂肪）和鳕鱼肝油（EPA和DHA能量为5％，ALA能量为5％，饱和脂肪为31％）。此外，在八个健康受试者中进行了体外PBMC实验，研究了EPA和ALA对炎症标志物释放和基因表达的影响。与禁食水平相比，摄食鳕鱼肝油饼后6 h IL-8 mRNA水平显着增加，这与亚麻子饼摄食后观察到的效果显着不同。相反，对IL-8的循环水平没有影响。另外，显示ALA和EPA对体外培养的PBMC中炎症标志物的释放和mRNA表达水平的影响不同，其中EPA具有最显着的促炎潜力

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