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首页> 外文期刊>The British Journal of Nutrition >Supplement of bamboo extract lowers serum monocyte chemoattractant protein-1 concentration in mice fed a diet containing a high level of saturated fat.
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Supplement of bamboo extract lowers serum monocyte chemoattractant protein-1 concentration in mice fed a diet containing a high level of saturated fat.

机译:补充竹提取物可降低喂食高含量饱和脂肪饮食的小鼠血清单核细胞趋化蛋白1的浓度。

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摘要

Monocyte chemoattractant protein-1 (MCP-1) is an inflammatory chemokine up-regulated in obese subjects, contributing to the development of type 2 diabetes. The present study investigated the inhibitory effect of an ethanol-water extract from bamboo (BEX, Phyllostachys edulis) on the blood concentration of MCP-1. C57BL/6J mice were fed a standard diet or a high-fat diet with or without the BEX supplement (11 g dry mass/17 000 kJ) for 6 months. A total of ten mice were used in each group. Body weight and food consumption were measured weekly. After euthanisation, the weight of visceral fat and circulating MCP-1 concentration were measured. In comparison with the standard control group, the high-fat control group had increased body weight, abdominal fat storage and serum MCP-1 concentration by 60 % (P < 0.001), 266% (P < 0.001) and 180% (P < 0.01), respectively. In comparison with the high-fat control group, the high-fat BEX group showed a 3% decrease in body weight (P < 0.01), 24% decrease in mesenteric fat depot (P < 0.01) and 49% decrease in serum MCP-1 concentration (P < 0.05). The present study suggests that the BEX supplement in the high-fat diet ameliorates elevated MCP-1 concentrations in the blood, and whether this is related to modulated endocrine properties of the visceral fat is to be studied
机译:单核细胞趋化蛋白1(MCP-1)是肥胖受试者中上调的炎症趋化因子,有助于2型糖尿病的发展。本研究研究了竹子中乙醇-水提取物(BEX,Phyllostachys edulis)对MCP-1血液浓度的抑制作用。给C57BL / 6J小鼠喂食标准饮食或高脂饮食,含或不含BEX补充剂(11 g干重/ 17 000 kJ)6个月。每组总共使用十只小鼠。每周测量体重和食物消耗。安乐死后,测量内脏脂肪的重量和循环MCP-1浓度。与标准对照组相比,高脂对照组的体重,腹部脂肪储存和血清MCP-1浓度增加了60%( P <0.001),266%( P <0.001)和180%( P <0.01)。与高脂对照组相比,高脂BEX组的体重下降了3%( P <0.01),肠系膜脂肪储库的体重下降了24%( P < / i> <0.01),血清MCP-1浓度降低49%( P <0.05)。本研究表明,高脂饮食中的BEX补充剂可以改善血液中MCP-1的升高浓度,这是否与内脏脂肪的内分泌特性调节有关?

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