Effect of Fluorous Tags on Glycosylation of Saccharide Primers in Animal Cells

Maria Carmelita Z. Kasuya; Mami Tojino; Shinya Nakano; Mamoru Mizuno; Kenichi Hatanaka

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Effect of Fluorous Tags on Glycosylation of Saccharide Primers in Animal Cells

机译：荧光标签对动物细胞糖苷引物糖基化的影响

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摘要

A series of fluorous-tagged saccharide primers with different contents of fluorous atoms was synthesized andintroduced into mouse melanoma B16 cells. The primers did not affect cell morphology and viability at a concentration of50μM. The numerous fluorine atoms did not pose a steric barrier to primer assimilation into cells and did not affectcellular-enzyme-catalyzed glycosylation. The lactoside primers were sialylated to afford GM3-type oligosaccharide. Onthe other hand, the GIcNAc primers were galactosylated to afford a lactosamine derivative that was further sialylated bycellular enzymes to afford a sialylated lactosamine.

机译：合成了一系列具有不同氟原子含量的含氟标签的糖引物，并将其引入小鼠黑素瘤B16细胞中。浓度为50μM时，引物不影响细胞的形态和活力。大量的氟原子不会对引物同化进入细胞构成空间位阻，也不会影响细胞酶催化的糖基化。乳糖苷引物被唾液酸化以提供GM3型寡糖。另一方面，将GIcNAc引物半乳糖基化以提供乳糖胺衍生物，其进一步被细胞酶唾液酸化以提供唾液酸化的乳糖胺。

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来源
《Bulletin of the Chemical Society of Japan》 |2009年第11期|共7页
作者
Maria Carmelita Z. Kasuya; Mami Tojino; Shinya Nakano; Mamoru Mizuno; Kenichi Hatanaka;
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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
Saccharide Primers; Animal Cells; Fluorous Tags;

机译：糖底漆;动物细胞;荧光标签;

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专利

1. Effect of Fluorous Tags on Glycosylation of Saccharide Primers in Animal Cells [J] . Maria Carmelita Z. Kasuya, Mami Tojino, Shinya Nakano, Bulletin of the Chemical Society of Japan . 2009,第11期

机译：荧光标签对动物细胞糖苷引物糖基化的影响
2. Glycosylation of N ~α-lauryl-O-(β-d-xylopyranosyl)-l- serinamide as a saccharide primer in cells [J] . Wang Y., Kumazawa T., Shiba K., Carbohydrate research . 2012,第Null期

机译：N〜α-月桂基-O-（β-d-吡喃吡喃糖基）-1-丝氨酰胺糖基化的糖基化
3. Glycosylation of dodecyl 2-acetamido-2-deoxy-beta-D-glucopyranoside and dodecyl beta-D-galactopyranosyl-(1 -> 4)-2-acetamido-2-deoxy-beta-D-glucopyranoside as saccharide primers in cells [J] . Sato T, Takashiba M, Hayashi R, Carbohydrate research . 2008,第5期

机译：十二烷基2-乙酰氨基-2-脱氧β-D-吡喃葡萄糖苷和十二烷基β-D-半乳糖吡喃糖基-（1-4）-2-乙酰胺基-2-脱氧β-D-吡喃葡萄糖苷的糖基化作用
4. INHIBITORY EFFECTS OF SEVERAL FLAVONOIDS ON PROSTAGLANDDS PRODUCTION AND E-SELECTIN EXPRESSION IN CULTURED ANIMAL CELLS [C] . Y. TAKANO-ISHIKAWA, M. GOTO, K. YAMAKI Annual Meeting of the Japanese Association for Animal Cell Technology . 2003

机译：None
5. Characterization of Dietary Saccharides and Their Effects on Cell Surface Glycosylation by LC-MS/MS [D] . Xu, Gege. 2018

机译：膳食糖的表征及其对细胞表面糖基化的影响（通过LC-MS / MS）
6. Glycoprotein biosynthesis in animal cells grown in suspension culture. Assembly of lipid-linked saccharides and formation of protein-bound 'high-mannose' oligosaccharides. [O] . D S Bailey, J Burke, R Sinclair, 2011

机译：在悬浮培养中生长的动物细胞中糖蛋白的生物合成。脂质连接糖的组装和蛋白质结合的“高甘露糖”寡糖的形成。
7. Glycoprotein biosynthesis in animal cells grown in suspension culture. Assembly of lipid-linked saccharides and formation of protein-bound 'high-mannose' oligosaccharides. [O] . Bailey, D S, Burke, J, Sinclair, R, 1981

机译：在悬浮培养中生长的动物细胞中糖蛋白的生物合成。脂质连接糖的组装和蛋白质结合的“高甘露糖”寡糖的形成。

Effect of Fluorous Tags on Glycosylation of Saccharide Primers in Animal Cells

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