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首页> 外文期刊>Biomaterials Science >Incorporation of sulfated hyaluronic acid macromers into degradable hydrogel scaffolds for sustained molecule delivery
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Incorporation of sulfated hyaluronic acid macromers into degradable hydrogel scaffolds for sustained molecule delivery

机译：将硫酸化的透明质酸大分子单体掺入可降解的水凝胶支架中，以实现持续的分子递送

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摘要

Synthetically sulfated hyaluronic acid (HA) has been shown to bind proteins with high affinity through electrostatic interactions. While HA-based hydrogels have been used widely in recent years for drug delivery and tissue engineering applications, incorporation of sulfated HA into these networks to attenuate the release of proteins is yet to be explored. Here, we developed sulfated and methacrylate-modified HA macromers and incorporated them into HA hydrogels through free radical-initiated crosslinking. The sulfated HA macromers bound to a heparin-binding protein (i.e., stromal cell-derived factor-1 alpha, SDF-1α) with an affinity comparable to heparin and did not alter the gelation behavior or network mechanics when copolymerized into hydrogels at low concentrations. Further, these macromers were incorporated into electrospun nanofibrous hydrogels to introduce sulfate groups into macroporous scaffolds. Once incorporated into either uniform or fibrous HA hydrogels, the sulfated HA macromers significantly slowed encapsulated SDF-1α release over 12 days. Thus, these macromers provide a useful way to introduce heparin-binding features into radical-crosslinked hydrogels to alter protein interactions for a range of applications.
机译：合成硫酸化透明质酸（HA）已显示通过静电相互作用以高亲和力结合蛋白质。尽管近年来基于HA的水凝胶已广泛用于药物递送和组织工程应用，但仍未探索将硫酸化的HA掺入这些网络以减弱蛋白质的释放。在这里，我们开发了硫酸化和甲基丙烯酸改性的HA大分子单体，并通过自由基引发的交联将其掺入HA水凝胶中。硫酸化的HA大分子单体以与肝素相当的亲和力与肝素结合蛋白（即基质细胞衍生的因子-1α，SDF-1α）结合，并且在低浓度共聚成水凝胶时不会改变凝胶行为或网络力学。此外，将这些大分子单体掺入电纺纳米纤维水凝胶中，以将硫酸根引入大孔支架中。一旦掺入到均匀或纤维状HA水凝胶中，硫酸化的HA大分子单体在12天内会大大减慢封装的SDF-1α的释放。因此，这些大分子单体提供了将肝素结合特征引入自由基交联的水凝胶以改变蛋白质相互作用的有用方法，以用于一系列应用。

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