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首页> 外文期刊>Biomaterials Science >Near-infrared light-triggered drug release nanogels for combined photothermal-chemotherapy of cancer
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Near-infrared light-triggered drug release nanogels for combined photothermal-chemotherapy of cancer

机译：近红外光触发药物释放纳米凝胶用于癌症的光热化学联合治疗

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Near-infrared (NIR) light-triggered drug release systems are promising for drug delivery applications in view of the advantages of NIR light, which include high tissue penetration and low damage. In this report, we developed nanogels (NGs) by supramolecular self-assembly from adamantine (AD)-conjugated copolymer, poly[poly(ethylene glycol)monomethyl ether metharcylate]-co-poly(N-(2-hydroxypropyl)methacrylamide)- co-poly(N-adamantan-1-yl-2-methacrylamide) (PPEGMA-co-PHPMA-co-PADMA), and beta-cyclodextrin (beta-CD)-functionalized poly(amidoamine) (PAMAM) dendrimer based on the host-guest interaction of the AD and beta-CD moieties, and they were used to encapsulate indocyanine green (ICG) and doxorubicin (DOX) for combined photothermal-chemotherapy. NGs simultaneously loading ICG and DOX (DINGs) showed significant photothermal effects and stimuli-triggered drug release under NIR laser irradiation by the photothermal-induced relaxation or dissociation of the NGs. In vitro cytotoxicity evaluation of DINGs under NIR irradiation demonstrated the synergistic effects of hyperthermia, photothermal-triggered drug release, and chemotherapy. In vivo investigation revealed their high accumulation in tumor tissue and significant tumor growth suppression under NIR irradiation. These NIR light-triggered drug release NGs represent efficient and promising anticancer drug vectors for the combined photothermal-chemotherapy of cancer to maximize therapeutic efficacy and minimize side effects.
机译：考虑到近红外（NIR）光的优点，包括高组织穿透力和低损伤性，近红外（NIR）光触发的药物释放系统有望用于药物输送。在本报告中，我们通过超分子自组装从金刚烷（AD）共轭共聚物，聚[聚（乙二醇）单甲醚甲基丙烯酸酯]-共聚（N-（2-羟丙基）甲基丙烯酰胺）-开发了纳米凝胶（NGs）。共聚（N-金刚烷-1-基-2-甲基丙烯酰胺）（PPEGMA-co-PHPMA-co-PADMA）和基于β-环糊精（β-CD）官能化的聚（酰胺基胺）（PAMAM）树枝状聚合物AD和β-CD部分的宿主-客体相互作用，并且它们被用于封装吲哚菁绿（ICG）和阿霉素（DOX）以用于联合光热化学疗法。 NG同时加载ICG和DOX（DING）表现出显着的光热效应，并且在NIR激光辐照下，NG通过光热诱导的NG松弛或离解而释放出刺激触发的药物。在NIR照射下对DINGs进行的体外细胞毒性评估证明了热疗，光热触发的药物释放和化学疗法的协同作用。体内研究表明，它们在肿瘤组织中高度聚集，并且在近红外照射下明显抑制了肿瘤的生长。这些NIR光触发的药物释放NG代表了有效且有前途的抗癌药物载体，可用于癌症的联合光热化学疗法，以最大化治疗功效并最小化副作用。

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