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Elastin-based biomaterials and mesenchymal stem cells

机译:基于弹性蛋白的生物材料和间充质干细胞

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摘要

Elastin is the dominant mammalian elastic protein found in soft tissue. Elastin-based biomaterials have the potential to repair elastic tissues by improving local elasticity and providing appropriate cellular interactions and signaling. Studies that combine these biomaterials with mesenchymal stem cells have demonstrated their capacity to also regenerate non-elastic tissue. Mesenchymal stem cell differentiation can be controlled by their immediate environment, and their sensitivity to elasticity makes them an ideal candidate for combining with elastin-based biomaterials. With the growing accessibility of the elastin precursor, tropoelastin, and elastin-derived materials, the amount of research interest in combining these two fields has increased and, subsequently, is leading to the realization of a potentially new strategy for regenerative medicine.
机译:弹性蛋白是在软组织中发现的主要的哺乳动物弹性蛋白。基于弹性蛋白的生物材料具有通过改善局部弹性并提供适当的细胞相互作用和信号传导来修复弹性组织的潜力。将这些生物材料与间充质干细胞结合在一起的研究表明,它们还具有再生非弹性组织的能力。间充质干细胞的分化可以通过其周围环境来控制,并且它们对弹性的敏感性使其成为与弹性蛋白基生物材料结合的理想候选者。随着弹性蛋白前体,原弹性蛋白和弹性蛋白衍生材料的可及性的日益提高,将这两个领域结合起来的研究兴趣越来越大,并且随后导致了再生医学的潜在新战略的实现。

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