首页> 外文期刊>The Indian Journal of Animal Reproduction >MHC IMMUN0GENET1CS INFLUENCES THE REPRODUCTION IN SHEEP
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MHC IMMUN0GENET1CS INFLUENCES THE REPRODUCTION IN SHEEP

机译:MHC IMMUN0GENET1CS影响绵羊的繁殖

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摘要

Experiment was conducted in four consecutive lambings to establish feto-maternal Immune response in a sheep flock of 639 animals. A total of 16 DRB_1 microsatellite alleles~3, ranging between 353 and 857 bp were detected which were associated with variable reproductive performances among males and females. Ewes carrying 411 bp allele exhibited higher values for all recorded fertility traits (p<0.001), followed by 386 bp allele whereas 389 bp allele had negative values in all fertility traits. The associations of different alleles with variable reproductive traits in sheep could be individual variability to humoral immune response, cell recognition or tissue differentiation between carriers of various MHC genotypes. The observed associations within DRB_1 microsatellite locus of Ovine MHC in German Merino sheep may be used as a molecular marker for identifying QTL in genetic improvement of the sheep and also quantifying the MHC Immunogenetic influences in the reproduction in sheep.
机译:在四只连续的羔羊中进行实验,以在639只动物的羊群中建立胎儿-母体的免疫反应。共检测到16个DRB_1微卫星等位基因〜3,范围在353和857 bp之间,与男性和女性的生殖能力不同有关。携带411 bp等位基因的母羊对所有记录的生育性状均表现出较高的值(p <0.001),其次是386 bp等位基因,而389 bp等位基因在所有生育性状中均呈负值。绵羊中不同等位基因与可变生殖特性的关联可能是体液免疫应答,细胞识别或各种MHC基因型携带者之间组织分化的个体变异性。在德国美利奴绵羊中,绵羊MHC的DRB_1微卫星基因座中观察到的关联可以用作分子标记,以鉴定绵羊遗传改良中的QTL,还可以量化MHC免疫原性对绵羊繁殖的影响。

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