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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Etude pilote de validation de I'administration de petits volumes de medicaments en pediatrie par voie intraveineuse directe avec solute primaire sur pompe volumetrique
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Etude pilote de validation de I'administration de petits volumes de medicaments en pediatrie par voie intraveineuse directe avec solute primaire sur pompe volumetrique

机译：通过容积泵上的主要溶液通过直接静脉内途径直接进行小剂量药物治疗的中试研究

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Background: Various systems may be used for intermittent parenteral administration of medications (minibags, mini-drip IV sets, burettes, direct administration). The objective of this study was to evaluate the feasibility of administering medications in volumes of less than 1 mL through the primary tubing of a solution flowing at a fixed rate.Methods: In this in vitro pilot study, sodium chloride (NaCl) 23.4% in aliquots of 1 mL or less was injected into the tubing of a sterile water solution flowing at a rate of 5 or 10 mL/h. The proportion of infused NaCl was calculated by sampling the residual amounts at the injection sites or was measured by collecting the actual amounts flowing out of the tubing.Results: A total of 266 trials were performed. After injection at the proximal site, with a flow rate of 5 mL/h, the proportion of NaCl infused, based on calculated values, was greater than the theoretical value, and the infusion times were too short. After injection at the distal site, with the same flow rate, the infused dose was administered slowly and predictably, that is, consistently more than 40% of the dose within 30 min. Lastly, after injection at the distal site, with a flow rate of 10 mL/h, administration of the maximum dose of 1 mL had a predictable duration of 30 min, with 50% of the dose administered after a maximum duration of infusion of 20 min.Conclusion: This pilot study confirms the feasibility of administering medications in volumes of less than 1 mL over periods of more than 5 min through the primary tubing of a solution flowing at a fixed rate. Further studies are necessary to confirm the application of this method in pediatrie care.
机译：背景：各种系统可用于间歇性肠胃外给药（微型袋，微型滴注IV套，滴定管，直接给药）。这项研究的目的是评估通过以固定速率流动的溶液的主输液管施用小于1毫升的药物的可行性。方法：在该体外试验研究中，氯化钠（NaCl）23.4％将等分试样的1 mL或更少的溶液注入以5或10 mL / h的流速流动的无菌水溶液的管中。通过采样注射部位的残留量来计算注入的氯化钠的比例，或者通过收集从管中流出的实际量来测量注入的氯化钠的比例。结果：总共进行了266次试验。在近端部位注射后，流速为5 mL / h，根据计算值计算，注入的NaCl比例大于理论值，并且注入时间过短。在远端部位以相同的流速注射后，缓慢且可预测地施用了注入剂量，即在30分钟内始终超过剂量的40％。最后，在远端部位以10 mL / h的流速注射后，最大剂量1 mL的给药可预测持续30分钟，最大输注20分钟后可给药50％最小结论：这项初步研究证实了通过固定流速的初级输液管在5分钟以上的时间内以小于1 mL的体积给药的可行性。有必要进行进一步的研究以确认该方法在儿科护理中的应用。

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