...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Canadian journal of hospital pharmacy. >Retrospective Analysis of Opioid Medication Incidents Requiring Administration of Naloxone
【24h】

Retrospective Analysis of Opioid Medication Incidents Requiring Administration of Naloxone

机译：需要纳洛酮治疗的阿片类药物事件的回顾性分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: : Opioid analgesics are high-alert medications known to cause adverse drug events. Objectives: The purpose of this study was to determine the cause of opioid incidents requiring administration of naloxone, an opioid reversal agent. The specific objectives were to determine the number of opioid incidents and the proportion of incidents documented through occurrence reporting and to characterize the incidents by phase in the medication-use process, by type of incident, and by drug responsible for toxic effects. Methods: A retrospective chart analysis was conducted using records from 2 acute care centres in the Regina QuAppelle Health Region. The study included inpatients who received naloxone for reversal of opioid toxicity resulting from licit, in-hospital opioid use. Cases were classified as preventable or nonpreventable. Preventable cases were analyzed to determine the phase of the medication-use process during which the incident occurred. These cases were also grouped thematically by the type of incident. The drug most likely responsible for opioid toxicity was determined for each case. The proportion of cases documented by occurrence reporting was also noted. Results: Thirty-six cases involving administration of naloxone were identified, of which 29 (81%) were deemed preventable. Of these 29 preventable cases, the primary medication incident occurred most frequently in the prescribing phase (23 [79%]), but multiple phases were often involved. The cases were grouped into 6 themes according to the type of incident. Morphine was the drug that most frequently resulted in toxic effects (18 cases [50%]). Only two of the cases (5.6%) were documented by occurrence reports. Conclusion: Preventable opioid incidents occurred in the acute care centres under study. A combination of medication safety initiatives involving multiple disciplines may be required to decrease the incidence of these events and to better document their occurrence.
机译：背景：阿片类镇痛药是已知会引起不良药物事件的高警戒药物。目的：本研究的目的是确定需要服用阿片类药物逆转剂纳洛酮的阿片类药物事件的原因。具体目标是确定阿片类药物事件的数量和通过事件报告记录的事件比例，并在药物使用过程中按阶段，事件类型以及负责毒性作用的药物对事件进行表征。方法：使用来自Regina QuAppelle卫生区的2个急性护理中心的记录进行回顾性图表分析。该研究包括接受纳洛酮逆转因在医院内合法使用阿片类药物而引起的阿片类药物毒性的住院患者。案件被分类为可预防或不可预防。对可预防的病例进行了分析，以确定事件发生期间药物使用过程的阶段。这些事件也按事件类型按主题分组。确定每种情况下最有可能导致阿片类药物毒性的药物。还注意到了通过事件报告记录的案件比例。结果：确定了36例涉及纳洛酮治疗的病例，其中29例（81％）被认为是可以预防的。在这29例可预防的病例中，主要用药事件在处方阶段最为频繁（23 [79％]），但通常涉及多个阶段。根据事件类型将案件分为6个主题。吗啡是最常引起毒性作用的药物（18例[50％]）。发生报告仅记录了其中两个案例（5.6％）。结论：正在研究的急性护理中心发生了可预防的阿片类药物事件。可能需要结合涉及多个学科的药物安全措施，以减少这些事件的发生率并更好地记录它们的发生。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号