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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Intermittent Intraperttoheal Administration of Magnesium Sulphate in an Elderly Patient Undergoing Dialysis
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Intermittent Intraperttoheal Administration of Magnesium Sulphate in an Elderly Patient Undergoing Dialysis

机译：接受透析的老年患者间歇性硫酸镁体内治疗

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摘要

Hypomagnesemia is not a typical concern in patients with stage 5 chronic kidney disease. Magnesium (Mg) is cleared renally, so Mg concentration is usually normal or even elevated in patients with chronic kidney disease. Up to 95% of renally filtered Mg can be reabsorbed in the nephron. Certain medications, such as diuretics (loop, thiazide, and osmotic), cisplatin, gentamicin, and E-lactam antibiotics, increase Mg excretion. The gastrointestinal absorption of Mg is dose-dependent and occurs by paracellular uptake at high Mg concentrations and by active transport at low Mg concentrations. Depending on the salt form, 30%-50% of ingested Mg is absorbed. Certain gastrointestinal disorders cause malab-sorption, and certain medications, such as proton-pump inhibitors, reduce absorption, either of which can lead to hypomagnesemia. Renal dysfunction can lead to hypermag-nesemia, yet gastrointestinal malabsorption can lead to hypomagnesemia; when these 2 conditions occur concurrently the change in serum magnesium is unpredictable.
机译：低镁血症不是患有5期慢性肾脏疾病的患者的典型问题。镁（Mg）通过肾脏清除，因此患有慢性肾脏疾病的患者中镁的含量通常正常，甚至升高。肾脏过滤的镁最多可再吸收95％。某些药物，例如利尿剂（环，噻嗪和渗透剂），顺铂，庆大霉素和E-内酰胺类抗生素，会增加Mg的排泄。胃肠道对镁的吸收是剂量依赖性的，并通过高镁浓度下的细胞旁摄取和低镁浓度下的主动转运而发生。根据盐的形式，摄入的镁的30％-50％被吸收。某些胃肠道疾病会引起吸收不良，某些药物（例如质子泵抑制剂）会降低吸收，这两种药物均会导致低镁血症。肾功能不全可导致高镁血症，而胃肠道吸收不良可导致低镁血症;当这两个条件同时发生时，血清镁的变化是不可预测的。

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