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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Experience with Extended Infusion of Piperacillin-Tazobactam at a Teaching Hospital
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Experience with Extended Infusion of Piperacillin-Tazobactam at a Teaching Hospital

机译：在教学医院长期输注哌拉西林-他唑巴坦的经验

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There has been increasing interest in the administration of beta-lactam antibiotics by either continuous or extended infusion as a means of achieving desired pharmacodynamic targets. In 2007, Lodise and others compared traditional dosing of piperacillin-tazobactam with an extended infusion regimen. Their results suggested improvements in terms of mortality and length of stay with the extended infusion for a subset of critically ill patients with infections due to Pseudomonas aeruginosa. In addition to improved patient outcomes, considerable cost savings were also realized at the authors' institution by using the extended infusion regimen. That article provided the impetus for our institution, a 1000-bed tertiary care teaching hospital, to undertake a pilot study to assess the feasibility of extended infusions. We encountered significant challenges during this pilot project, but even though our endeavour was ultimately unsuccessful, we identified a number of barriers that may be informative to other institutions attempting to incorporate extended infusions into their practice.
机译：通过连续输注或延长输注作为达到所需药效学目标的手段，人们对β-内酰胺类抗生素的给药越来越感兴趣。 2007年，Lodise等人将哌拉西林-他唑巴坦的传统剂量与延长的输注方案进行了比较。他们的研究结果表明，对于因铜绿假单胞菌感染而感染的部分危重患者，延长输注时间可提高死亡率和住院时间。除了改善患者的预后外，通过使用延长的输注方案，作者所在的机构还实现了可观的成本节省。该文章为我们的机构提供了动力，这家拥有1000张床的三级护理教学医院可以进行一项初步研究，以评估长期输液的可行性。在该试点项目期间，我们遇到了重大挑战，但是，尽管我们的努力最终没有成功，但我们发现了许多障碍，这些障碍可能对其他试图将扩展输注纳入其实践的机构有所帮助。

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