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Physical compatibility of high-concentration bupivacaine with hydromorphone, morphine, and fentanyl

机译:高浓度布比卡因与氢吗啡酮,吗啡和芬太尼的物理相容性

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摘要

In the field of oncology and in the setting of chronic pain, there are subsets of patients whose pain is refractory to usual drug dosages. Instead, to achieve acceptable pain control, combinations of local anesthetics and narcotics at elevated concentrations are required. Although there is some literature on the compatibility of various combinations of these drugs, our institution needed data for these more concentrated solutions. To ensure patient safety and to ensure that acceptable expiry data were available, we performed physical compatibility testing for these more highly concentrated solutions.
机译:在肿瘤学领域和慢性疼痛的治疗中,有一部分患者的疼痛对于常规药物剂量是难治的。相反,为了实现可接受的疼痛控制,需要将局部麻醉药和麻醉药以高浓度联合使用。尽管有一些关于这些药物各种组合的相容性的文献,但我们机构需要这些更集中的解决方案的数据。为了确保患者安全并确保可以接受可接受的有效期数据,我们对这些浓度更高的解决方案进行了物理兼容性测试。

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