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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Ertapenem-lnduced Reduction in Valproate Levels: Case Report and Review of the Literature
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Ertapenem-lnduced Reduction in Valproate Levels: Case Report and Review of the Literature

机译：厄他培南诱导的丙戊酸盐水平降低：病例报告和文献复习

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The concomitant use of carbapenems and valproate is not recommended because carbapenems may decrease serum concentrations of valproate. Increasing the dose of valproate may not compensate for the reduction, which puts the patient at risk for recurrent seizures. Therefore, close monitoring of valproate levels is necessary when initiating a carbapenem antibiotic in patients whose condition has been stabilized with valproate therapy.Several case reports of significant reductions in serum valproate concentrations following initiation of carbapenem antibiotics have been published. To the authors' knowledge, however, there has been no published systematic review of the carbapenem-valproate interaction. We report a case of ertapenem-induced reduction in valproate concentration and describe the extent, clinical relevance, potential mechanisms, and therapeutic options for management of the carbapenem-valproate interaction.
机译：不建议同时使用碳青霉烯类和丙戊酸盐，因为碳青霉烯可能会降低丙戊酸盐的血清浓度。丙戊酸盐剂量的增加可能无法弥补减少的剂量，这会使患者处于反复发作的危险中。因此，在丙戊酸钠治疗已使病情稳定的患者中，开始使用碳青霉烯类抗生素时，必须密切监测丙戊酸水平。几例报道了在开始使用碳青霉烯类抗生素后血清丙戊酸浓度显着降低的病例报道。然而，据作者所知，尚未发表有关碳青霉烯-丙戊酸酯相互作用的系统综述。我们报告一例厄他培南诱导的丙戊酸钠浓度降低的情况，并描述了碳青霉烯-丙戊酸盐相互作用的程度，临床相关性，潜在机制和治疗选择。

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