首页> 外文期刊>The Canadian journal of clinical pharmacology =: Journal canadien de pharmacologie clinique >Adverse effects in neonates exposed to SSRIs and SNRI in late gestation
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Adverse effects in neonates exposed to SSRIs and SNRI in late gestation

机译:妊娠后期暴露于SSRI和SNRI的新生儿的不良反应

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摘要

Neonates exposed at term to selective serotonine (SSRI) or serotonine-norepinephrine reuptake inhibitors (SNRI) medications may encounter symptoms such as irritability, rigid ity, tremor and respiratory distress. Most available data suggest that these self limited symptoms are due to discontinuation of the drug, although there are documented cases of symptoms associated with high serum concentrations in the neonate that subsided when levels fall. Preliminary evidence suggests that the very early respiratory symptoms may not be part of discontinuation but rather part of a reversible form of persistent pulmonary hypertension of the newborn (PPHN).
机译:足月接触选择性5-羟色胺(SSRI)或5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI)药物的新生儿可能会遇到诸如烦躁,僵硬,震颤和呼吸窘迫等症状。大多数现有数据表明,这些自我限制的症状是由于药物的停用而引起的,尽管有证据表明,与新生儿血清中高浓度的症状有关的症状会在水平下降时消失。初步证据表明,早期呼吸道症状可能不是停药的一部分,而是新生儿持续性肺动脉高压(PPHN)的可逆形式的一部分。

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