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首页> 外文期刊>The Canadian journal of clinical pharmacology =: Journal canadien de pharmacologie clinique >Herbs, vitamins and minerals in the treatment of premenstrual syndrome: A systematic review
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Herbs, vitamins and minerals in the treatment of premenstrual syndrome: A systematic review

机译：草药，维生素和矿物质治疗经前期综合征：系统评价

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摘要

Background: As many women experiencing symptoms of premenstrual syndrome (PMS) seek relief from natural products (NP), health care providers should have quality information available to aid women in making evidence-based decisions regarding use of these products. Objective: To identify herbs, vitamins and minerals advocated for the treatment of PMS and/or PMDD and to systematically review evidence from randomized controlled trials (RCTs) to determine their efficacy in reducing severity of PMS/PMDD symptoms. Methods: Searches were conducted from inception to April 2008 in Clinical Evidence, The Cochrane Library, Embase, IBID, IPA, Mayoclinic, Medscape, MEDLINE Plus, Natural Medicines Comprehensive Database and the Internet to identify RCTs of herbs, vitamins or minerals advocated for PMS. Bibliographies of articles were also examined. Included studies were published in English or French. Studies were excluded if patient satisfaction was the sole outcome measure or if the comparator was not placebo or recognized therapy. Results: Sixty-two herbs, vitamins and minerals were identified for which claims of benefit for PMS were made, with RCT evidence found for only 10. Heterogeneity of length of trials, specific products and doses, and outcome measures precluded meta-analysis for any NP. Data supports the use of calcium for PMS, and suggests that chasteberry and vitamin B6 may be effective. Preliminary data shows some benefit with ginkgo, magnesium pyrrolidone, saffron, St. John's Wort, soy and vitamin E. No evidence of benefit with evening primrose oil or magnesium oxide was found. Conclusion: Only calcium had good quality evidence to support its use in PMS. Further research is needed, using RCTs of adequate length, sufficient sample size, well-characterized products and measuring the effect on severity of individual PMS symptoms.
机译：背景：随着许多患有经前期综合症（PMS）症状的妇女寻求天然产品（NP）的缓解，医疗保健提供者应掌握高质量的信息，以帮助妇女做出有关使用这些产品的循证决策。目的：确定提倡用于治疗PMS和/或PMDD的草药，维生素和矿物质，并系统地回顾来自随机对照试验（RCT）的证据，以确定其在减轻PMS / PMDD症状严重性方面的功效。方法：从开始到2008年4月，在临床证据，Cochrane图书馆，Embase，IBID，IPA，Mayoclinic，Medscape，MEDLINE Plus，天然药物综合数据库和互联网上进行搜索，以鉴定提倡用于PMS的草药，维生素或矿物质的RCT 。还检查了文章的书目。纳入的研究以英文或法文出版。如果患者满意度是唯一的结局指标，或者比较者不是安慰剂或公认的治疗方法，则排除研究。结果：确定了62种草药，维生素和矿物质，声称对PMS有益处，仅10项发现了RCT证据。试验时间，特定产品和剂量的异质性以及结局指标排除了任何方法的荟萃分析NP。数据支持在PMS中使用钙，并表明Chasteberry和维生素B6可能有效。初步数据显示，银杏，吡咯烷酮镁，藏红花，圣约翰草，大豆和维生素E有益。未发现有月见草油或氧化镁有益的证据。结论：只有钙具有良好的质量证据支持其在PMS中的使用。需要使用足够长的随机对照试验，足够的样本量，特征明确的产品以及测量对个体PMS症状严重程度的影响，需要进行进一步的研究。

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